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Seiryo Sugiura
Researcher at University of Tokyo
Publications - 150
Citations - 6163
Seiryo Sugiura is an academic researcher from University of Tokyo. The author has contributed to research in topics: Myosin & Heart failure. The author has an hindex of 33, co-authored 147 publications receiving 5694 citations.
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Journal ArticleDOI
CD8 + effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
Satoshi Nishimura,Ichiro Manabe,Mika Nagasaki,Koji Eto,Hiroshi Yamashita,Mitsuru Ohsugi,Makoto Otsu,Hara Kazuo,Kohjiro Ueki,Seiryo Sugiura,Kotaro Yoshimura,Takashi Kadowaki,Ryozo Nagai +12 more
TL;DR: The findings suggest that obese adipose tissue activates CD8+ T cells, which, in turn, promote the recruitment and activation of macrophages in this tissue, which supports the notion that CD8- T cells have an essential role in the initiation and propagation of adipose inflammation.
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Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels.
Satoshi Nishimura,Ichiro Manabe,Mika Nagasaki,Yumiko Hosoya,Hiroshi Yamashita,Hideo Fujita,Mitsuru Ohsugi,Kazuyuki Tobe,Takashi Kadowaki,Ryozo Nagai,Seiryo Sugiura +10 more
TL;DR: Living tissue imaging techniques provide novel evidence of the dynamic interactions between differentiating adipocytes, stromal cells, and angiogenesis in living obese adipose tissue.
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A mouse model of vascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia.
Masataka Sata,Yoshie Maejima,Fumiko Adachi,Keiko Fukino,Akio Saiura,Seiryo Sugiura,Teruhiko Aoyagi,Yasushi Imai,Hiroki Kurihara,Kenjiro Kimura,Masao Omata,Masatoshi Makuuchi,Yasunobu Hirata,Ryozo Nagai +13 more
TL;DR: This model may be widely used to study the molecular mechanism of post-angioplasty restenosis at the genetic level.
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In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue
Satoshi Nishimura,Ichiro Manabe,Mika Nagasaki,Kinya Seo,Hiroshi Yamashita,Yumiko Hosoya,Mitsuru Ohsugi,Kazuyuki Tobe,Takashi Kadowaki,Ryozo Nagai,Seiryo Sugiura +10 more
TL;DR: An imaging technique based on confocal laser microscopy enabled to analyze and compare the 3-dimensional structures, cellular dynamics, and vascular function within mouse lean and obese adipose tissue in vivo with high spatiotemporal resolution allowed it to be a valuable tool to evaluate potential therapeutic interventions.
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Multiphysics simulation of left ventricular filling dynamics using fluid-structure interaction finite element method.
TL;DR: A three-dimensional finite-element-based simulation program incorporating the cellular mechanisms of excitation-contraction coupling and its propagation is developed, and the fluid-structure interaction involved in the contraction and relaxation of the human left ventricle is simulated.