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Seitaro Nomura
Researcher at University of Tokyo
Publications - 60
Citations - 1516
Seitaro Nomura is an academic researcher from University of Tokyo. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 14, co-authored 42 publications receiving 827 citations. Previous affiliations of Seitaro Nomura include Jichi Medical University.
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Journal ArticleDOI
Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction
Shintaro Yamada,Toshiyuki Ko,Satoshi Hatsuse,Seitaro Nomura,B. Y. Zhang,Zhehao Dai,Shunsuke Inoue,Masayuki Kubota,Kosuke Sawami,Takanobu Yamada,Tatsuro Sassa,Mika Katagiri,Kanna Fujita,Manami Katoh,Masamichi Ito,Mutsuo Harada,Haruhiro Toko,Norifumi Takeda,Hiroyuki Morita,Hiroyuki Aburatani,Issei Komuro +20 more
TL;DR: In this article , the authors performed an integrative analysis of spatial transcriptomics and single-nucleus RNA sequencing (snRNA-seq) in a murine MI model and found that mechanical stress-response genes are expressed at the border zone and play a critical role in left ventricular remodeling after MI.
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Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction
Kazuo Miyazawa,Kaoru Ito,Masamichi Ito,Zhaonan Zou,Masayuki Kubota,Seitaro Nomura,Hiroshi Matsunaga,Satoshi Koyama,Hirotaka Ieki,Masato Akiyama,Yoshinao Koike,R. Kurosawa,Hiroki Yoshida,Kouichi Ozaki,Yoshihiro Onouchi,Koichi Yoshinori Yoichiro Matsuda Murakami Kamatani,Yoshinori Murakami,Atsushi Takahashi,Koichi Matsuda,Hiroyuki Aburatani,Michiaki Kubo,Yukihide Momozawa,Chikashi Terao,Shinya Oki,Hiroshi Akazawa,Yoichiro Kamatani,Issei Komuro +26 more
TL;DR: The authors performed a genome-wide association study in the Japanese population comprising 9,826 cases among 150,272 individuals and identified East Asian specific rare variants associated with atrial fibrillation.
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Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: Purification of peptide E as a low-affinity ligand for mammalian bombesin receptors
Yuichi Ikeda,Hidetoshi Kumagai,Hiroaki Okazaki,Mitsuhiro Fujishiro,Yoshihiro Motozawa,Seitaro Nomura,Norifumi Takeda,Haruhiro Toko,Eiki Takimoto,Hiroshi Akazawa,Hiroyuki Morita,Jun-ichi Suzuki,Tsutomu Yamazaki,Issei Komuro,Masashi Yanagisawa +14 more
TL;DR: A cell-based assay for monitoring ligand-dependent GPCR-β-arrestin interaction via β-lactamase enzyme fragment complementation is developed and it is concluded that this newly developed system will facilitate the discovery of G PCR ligands.
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Precision medicine for heart failure based on molecular mechanisms: The 2019 ISHR Research Achievement Award Lecture.
Seitaro Nomura,Issei Komuro +1 more
TL;DR: The approaches for investigating the molecular mechanisms of cardiac hypertrophy, development, and failure are introduced and future perspectives are discussed to discuss future perspectives.
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Functional Evaluation of Human Bioengineered Cardiac Tissue Using iPS Cells Derived from a Patient with Lamin Variant Dilated Cardiomyopathy.
Koichi Miura,Katsuhisa Matsuura,Yu Yamasaki Itoyama,Daisuke Sasaki,Takuma Takada,Yoshiyuki Furutani,Emiko Hayama,Masamichi Ito,Seitaro Nomura,Hiroyuki Morita,Masashi Toyoda,Akihiro Umezawa,Kenji Onoue,Yoshihiko Saito,Hiroyuki Aburatani,Toshio Nakanishi,Nobuhisa Hagiwara,Issei Komuro,Tatsuya Shimizu +18 more
TL;DR: Human iPS-derived bioengineered cardiac tissue with the LMNA p.R225X mutation has the functional properties of systolic dysfunction and may be a promising tissue model for understanding the underlying mechanisms of DCM.