E
Eiki Takimoto
Researcher at University of Tokyo
Publications - 65
Citations - 2520
Eiki Takimoto is an academic researcher from University of Tokyo. The author has contributed to research in topics: Pressure overload & Heart failure. The author has an hindex of 22, co-authored 65 publications receiving 2048 citations. Previous affiliations of Eiki Takimoto include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4.
Koshiro Monzen,Ichiro Shiojima,Yukio Hiroi,Sumiyo Kudoh,Toru Oka,Eiki Takimoto,Doubun Hayashi,Toru Hosoda,Akemi Habara-Ohkubo,Takashi Nakaoka,Toshiro Fujita,Yoshio Yazaki,Issei Komuro +12 more
TL;DR: The results suggest that TAK1, Csx/Nkx-2.5, and GATA-4 play a pivotal role in the cardiogenic BMP signaling pathway.
Journal ArticleDOI
Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure
Takehiro Kamo,Hiroshi Akazawa,Wataru Suda,Wataru Suda,Akiko Saga-Kamo,Yu Shimizu,Hiroki Yagi,Qing Liu,Seitaro Nomura,Atsuhiko T. Naito,Norifumi Takeda,Mutsuo Harada,Haruhiro Toko,Hidetoshi Kumagai,Yuichi Ikeda,Eiki Takimoto,Jun-ichi Suzuki,Kenya Honda,Hidetoshi Morita,Masahira Hattori,Masahira Hattori,Issei Komuro +21 more
TL;DR: It is suggested that patients with HF harbor significantly altered gut microbiota, which varies further according to age, and new concept of heart-gut axis has a great potential for breakthroughs in the development of novel diagnostic and therapeutic approach for HF.
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Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
Seitaro Nomura,Masahiro Satoh,Takanori Fujita,Tomoaki Higo,Tomokazu Sumida,Toshiyuki Ko,Toshihiro Yamaguchi,Takashige Tobita,Atsuhiko T. Naito,Masamichi Ito,Kanna Fujita,Mutsuo Harada,Haruhiro Toko,Yoshio Kobayashi,Kaoru Ito,Eiki Takimoto,Hiroshi Akazawa,Hiroyuki Morita,Hiroyuki Aburatani,Issei Komuro +19 more
TL;DR: The authors identify the gene programs encoding the morphological and functional characteristics of cardiomyocytes during the transition from early hypertrophy to heart failure via single-cell transcriptomics, establishing a key role for p53 signalling.
Journal ArticleDOI
Frequency- and Afterload-Dependent Cardiac Modulation In Vivo by Troponin I With Constitutively Active Protein Kinase A Phosphorylation Sites
Eiki Takimoto,David G. Soergel,Paul M.L. Janssen,Linda B. Stull,David A. Kass,Anne M. Murphy +5 more
TL;DR: A novel role for cardiac TnI PKA phosphorylation in the rate-dependent enhancement of systolic and diastolic function in vivo and afterload sensitivity of relaxation is supported, which has implications for cardiac failure in which force-frequency modulation is blunted and after load relaxation sensitivity increased in association with diminished PKA Tni phosphorylated.
Journal ArticleDOI
Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation.
Koshiro Monzen,Yukio Hiroi,Sumiyo Kudoh,Hiroshi Akazawa,Toru Oka,Eiki Takimoto,Doubun Hayashi,Toru Hosoda,Masahiro Kawabata,Kohei Miyazono,Shunsuke Ishii,Yoshio Yazaki,Ryozo Nagai,Issei Komuro +13 more
TL;DR: The results suggest that Smads, TAK1, and their common target ATF-2 cooperatively play a critical role in cardiomyocyte differentiation.