Selina M. Vattathil

TL;DR: In this article , the authors integrate the GWAS results with human brain transcriptomes and proteomes to identify cis-and trans- transcripts and proteins that are consistent with a pleiotropic or causal role in each disease, referred to as causal proteins.

TL;DR: The findings identify potentially important modifiable factors as targets for intervention strategies to enhance PiL, including perceived social support, more social activities, more years of education, higher income, intact late-life cognitive performance, and more middle-age cognitive activities.

TL;DR: LDL-C was associated with all measures of AD neuropathology and cerebral amyloid angiopathy independent of APOE after adjusting for age, sex, cholesterol-lowering medication use, body mass index, smoking and education at false discovery rate (FDR) p-value <0.05 and suggest LDL-C is a modifiable risk factor for AD.

TL;DR: In this article, the authors examined the association of common single nucleotide polymorphisms with cerebral atherosclerosis severity and found that the SNPs may influence brain protein expression of CNOT3, which has been shown to be a master regulator of mRNA stability and translation.

TL;DR: In this paper , major psychiatric disorders such as major depressive disorder (MDD), bipolar disorder, schizophrenia, anxiety disorders, PTSD, and alcohol use disorder affect approximately 25% of the population annually; however, their treatments are effective in only a subset of the patients.