S
Seong-Tae Kim
Researcher at Sungkyunkwan University
Publications - 92
Citations - 7281
Seong-Tae Kim is an academic researcher from Sungkyunkwan University. The author has contributed to research in topics: Phosphorylation & DNA damage. The author has an hindex of 35, co-authored 83 publications receiving 6898 citations. Previous affiliations of Seong-Tae Kim include New Generation University College & UPRRP College of Natural Sciences.
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Journal ArticleDOI
Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members
TL;DR: A general phosphorylation consensus sequence for ATM is determined and putative in vitro targets are identified by using glutathioneS-transferase peptides as substrates by utilizing p53 peptide mutagenesis analysis.
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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
Dae-Sik Lim,Seong-Tae Kim,Bo Xu,Richard S. Maser,Junyu Lin,John H.J. Petrini,Michael B. Kastan +6 more
TL;DR: Observations link ATM and p95/nbs1 in a common signalling pathway and provide an explanation for phenotypic similarities in these two diseases.
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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
Ruth Maya,Moshe Balass,Seong-Tae Kim,Dganit Shkedy,Juan-Fernando Martinez Leal,Ohad Shifman,Miri Moas,Thomas Buschmann,Ze'ev Ronai,Yosef Shiloh,Michael B. Kastan,Ephraim Katzir,Moshe Oren +12 more
TL;DR: In this paper, a consensus 2A10 recognition sequence, possessing the core motif DYS, was identified twice within the human Mdm2 molecule, at positions corresponding to residues 258−260 and 393−395.
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Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation.
TL;DR: The results clarify the checkpoint roles for each of these three gene products, demonstrate that control of cell cycle arrests must now be included among the important functions of Brca1 in cellular responses to DNA damage, and suggest that Atm phosphorylation of BrCA1 is required for the G2/M checkpoint.
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Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
TL;DR: It is shown that the protein kinase, Atm, which belongs to a family of phosphatidylinositol 3-kinases that regulate cell cycle checkpoints and DNA recombination and repair, phosphorylates Smc1 protein after ionizing irradiation.