S
Serge Charpak
Researcher at Paris Descartes University
Publications - 59
Citations - 7755
Serge Charpak is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Olfactory bulb & Cerebral blood flow. The author has an hindex of 32, co-authored 53 publications receiving 6590 citations. Previous affiliations of Serge Charpak include University of Paris & French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
Glial and neuronal control of brain blood flow.
David Attwell,Alastair M. Buchan,Serge Charpak,Martin Lauritzen,Brian A. MacVicar,Eric A. Newman +5 more
TL;DR: It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles.
Journal ArticleDOI
Glutamate Released from Glial Cells Synchronizes Neuronal Activity in the Hippocampus
TL;DR: It is demonstrated in hippocampal slices of 2- to 5-week-old rats that glutamate released from glial cells generates slow transient currents (STCs) mediated by the activation of NMDA receptors in pyramidal cells, indicating a nonsynaptic origin of the source of glutamate.
Journal ArticleDOI
Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host
Bertrand Léobon,Isabelle Garcin,Philippe Menasché,Jean-Thomas Vilquin,Etienne Audinat,Serge Charpak +5 more
TL;DR: Results indicate that grafted myoblasts differentiate into peculiar hyperexcitable myotubes with a contractile activity fully independent of neighboring cardiomyocytes, concluding that mechanisms other than electromechanical coupling between grafted and host cells are involved in the improvement of cardiac function.
Journal ArticleDOI
Two-photon microscopy in brain tissue: parameters influencing the imaging depth.
TL;DR: An improved low-magnification, high-numerical aperture objective is proposed that should allow fluorescence measurements related to neuronal or vascular brain activity at >100 microm deeper than with standard objectives.
Journal ArticleDOI
Perivascular spaces in the brain: anatomy, physiology and pathology
Joanna M. Wardlaw,Helene Benveniste,Berislav V. Zlokovic,Humberto Mestre,Hedok Lee,Fergus N. Doubal,Rosalind Brown,Joel Ramirez,Joel Ramirez,Bradley J. MacIntosh,Bradley J. MacIntosh,Allen Tannenbaum,Lucia Ballerini,Ravi L. Rungta,Davide Boido,Melanie D. Sweeney,Axel Montagne,Serge Charpak,Anne Joutel,Kenneth Smith,Sandra E. Black,Sandra E. Black +21 more
TL;DR: Experimental models show that perivascular spaces are important conduits for uptake of cerebrospinal fluid to flush interstitial fluid and clear metabolic waste; these processes seem to increase during sleep.