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Serge Garbay
Researcher at French Institute of Health and Medical Research
Publications - 21
Citations - 1295
Serge Garbay is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Nephron & Transcription factor. The author has an hindex of 13, co-authored 19 publications receiving 1137 citations. Previous affiliations of Serge Garbay include Pasteur Institute & University of Paris.
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Journal ArticleDOI
A transcriptional network in polycystic kidney disease
Lionel Gresh,Evelyne Fischer,Andreas Reimann,Myriam Tanguy,Serge Garbay,Xinli Shao,Thomas Hiesberger,Laurence Fiette,Peter Igarashi,Moshe Yaniv,Marco Pontoglio +10 more
TL;DR: It is reported here that mice with renal‐specific inactivation of HNF1β develop polycystic kidney disease, and it is shown that renal cyst formation is accompanied by a drastic defect in the transcriptional activation of Umod, Pkhd1 and Pkd2 genes, whose mutations are responsible for distinct cystic kidney syndromes.
Journal ArticleDOI
A mitotic transcriptional switch in polycystic kidney disease
Francisco Verdeguer,Stéphanie Le Corre,Evelyne Fischer,Celine Callens,Serge Garbay,Antonia Doyen,Peter Igarashi,Fabiola Terzi,Marco Pontoglio +8 more
TL;DR: It is shown here that inactivation of Hnf1b from postnatal day 10 onward does not elicit cystic dilations in tubules after their proliferative morphogenetic elongation is over, which suggests that HNF-1β is a bookmarking factor that is necessary for reopening the chromatin of target genes after mitotic silencing.
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Hepatocyte nuclear factor 1β controls nephron tubular development
Filippo Massa,Serge Garbay,Raymonde Bouvier,Yoshinobu Sugitani,Tetsuo Noda,Marie-Claire Gubler,Laurence Heidet,Marco Pontoglio,Evelyne Fischer +8 more
TL;DR: A novel hierarchical relationship between HNF1β and key genes involved in renal development is revealed and a novel structural and functional component of S-shaped bodies at the origin of tubule formation is defined.
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Papillomavirus E2 induces p53-independent apoptosis in HeLa cells
TL;DR: Observations show that E2-induced apoptosis is an early event, independent of p53 accumulation and unrelated to downstream p53-dependent transcriptional events.
Journal ArticleDOI
The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation
Lionel Gresh,Brigitte Bourachot,Andreas Reimann,Bruno Guigas,Laurence Fiette,Serge Garbay,Christian Muchardt,Louis Hue,Marco Pontoglio,Moshe Yaniv,Agnes Klochendler-Yeivin +10 more
TL;DR: The results emphasize the role of chromatin remodeling in the activation of cell‐type‐specific genetic programs and driving cell differentiation in SNF5‐deleted cells.