Serge Garbay

TL;DR: This study identifies new direct target genes of the Hnf1 transcription factors and shows that they play crucial roles in both defining cell fate and controlling terminal functions in the gut epithelium.

TL;DR: A genome-wide map of p53 binding sites (p53BS) is generated and it is shown that the presence of nearby p53BS can identify new proapoptotic members of the Bcl2 family and that induction of this gene contributes to p53-mediated apoptosis.

TL;DR: A molecular link between tubular and interstitial cells during CKD progression is provided and Stat3 is identified as a central regulator of this link and a promising therapeutic target.

TL;DR: This work has developed a computational method for the genome-wide identification of functional transcription factor binding sites based on positional weight matrices, comparative genomics, and gene expression profiling that appears to be a valid alternative to high-throughput experimental assays for the discovery of novel direct targets of transcription factors.

TL;DR: It is shown that HNF1β bookmarking activity is impaired by naturally occurring mutations found in patients, and it is demonstrated that importin-β is involved in the maintenance of the mitotic retention of H NF1β, suggesting a functional link between the nuclear import system and theMitotic localization/translocation of bookmarking factors.