L
Laurence Heidet
Researcher at Necker-Enfants Malades Hospital
Publications - 105
Citations - 5271
Laurence Heidet is an academic researcher from Necker-Enfants Malades Hospital. The author has contributed to research in topics: Alport syndrome & Kidney disease. The author has an hindex of 38, co-authored 92 publications receiving 4379 citations. Previous affiliations of Laurence Heidet include Hospital Sant Joan de Déu Barcelona & Sorbonne.
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Journal ArticleDOI
Early angiotensin-converting enzyme inhibition in Alport syndrome delays renal failure and improves life expectancy
Oliver Gross,Christoph Licht,Hans J. Anders,Bernd Hoppe,Bodo B. Beck,Burkhard Tönshoff,Britta Höcker,Simone Wygoda,Jochen H. H. Ehrich,Lars Pape,Martin Konrad,Wolfgang Rascher,Jörg Dötsch,Dirk E. Müller-Wiefel,Peter F. Hoyer,Bertrand Knebelmann,Yves Pirson,Jean-Pierre Grünfeld,Patrick Niaudet,Pierre Cochat,Laurence Heidet,Said Lebbah,Roser Torra,Tim Friede,Katharina Lange,Gerhard A. Müller,Manfred Weber +26 more
TL;DR: Alport syndrome is treatable with angiotensin-converting enzyme inhibition to delay renal failure and therapy improves life expectancy in a time-dependent manner and supports the need for early diagnosis and early nephroprotective therapy in oligosymptomatic patients.
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Early glomerular filtration defect and severe renal disease in podocin-deficient mice.
Séverine Roselli,Laurence Heidet,Mireille Sich,Anna Henger,Matthias Kretzler,Marie Claire Gubler,Corinne Antignac +6 more
TL;DR: The crucial role of podocin in the establishment of the glomerular filtration barrier is demonstrated and Nphs2 −/− mice provide a suitable model for mapping and identifying modifier genes involved in glomerULAR diseases caused by podocyte injuries.
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Spectrum of HNF1B mutations in a large cohort of patients who harbor renal diseases.
Laurence Heidet,Stéphane Decramer,Audrey Pawtowski,Vincent Morinière,Flavio Bandin,Bertrand Knebelmann,Anne-Sophie Lebre,Stanislas Faguer,Vincent Guigonis,Corinne Antignac,Rémi Salomon +10 more
TL;DR: The severity of the renal disease associated with HNF1B mutations was extremely variable (from prenatal renal failure to normal renal function in adulthood) and was not correlated with the genotype.
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Expression of the Nonmuscle Myosin Heavy Chain IIA in the Human Kidney and Screening for MYH9 Mutations in Epstein and Fechtner Syndromes
Christelle Arrondel,Nicolas Vodovar,Bertrand Knebelmann,Jean-Pierre Grünfeld,Marie-Claire Gubler,Corinne Antignac,Laurence Heidet +6 more
TL;DR: The expression of MYH9 in the fetal and mature human kidney was studied, and the 40 coding exons of the gene were screened by single-strand conformation polymorphism in 12 families presenting with the association of MTCP and nephropathy.
Journal ArticleDOI
COL4A3/COL4A4 mutations: from familial hematuria to autosomal-dominant or recessive Alport syndrome.
Ilaria Longo,Paola Porcedda,Francesca Mari,Daniela Giachino,Ilaria Meloni,Carla Deplano,Alfredo Brusco,Maurizio Bosio,Laura Massella,Giancarlo Lavoratti,Dario Roccatello,Giovanni M. Frascà,Gianna Mazzucco,Andrea Onetti Muda,Maura Conti,Federica Fasciolo,Christelle Arrondel,Laurence Heidet,Alessandra Renieri,Mario De Marchi +19 more
TL;DR: The mutation spectrum of COL4A3 andCOL4A4 genes is extended, and a possible relationship between production of abnormal COL IV chains and dominant expression of a continuous spectrum of phenotypes is suggested, from ATS to BFH.