Sergei Korneev

TL;DR: Results show that a natural antisense mechanism can mediate the translational control of nNOS expression in the Lymnaea CNS and suggest that transcribed pseudogenes are not entirely without purpose and are a potential source of a new class of regulatory gene in the nervous system.

TL;DR: A photoactivatable ceramide probe combined with a computation approach and functional studies support a role of VDAC2 as direct effector of ceramide-mediated cell death, providing a molecular framework for how ceramides exert their anti-neoplastic activity.

TL;DR: The molecular characterization of the first molluscan NOS in the CNS of the pond snail Lymnaea stagnalis is reported, which contains tandem repeats of a seven amino acid motif not found in any other known NOS.

TL;DR: This appears to be the first report of the timed and targeted differential regulation of the activity of a group of related genes involved in the production of a neurotransmitter that is necessary for learning, measured in an identified neuron of known function and the first example of the behavioral regulation of a pseudogene.

TL;DR: Hyperphagia mediated by drug-induced impairments in satiety (as evidenced by increased meal size) is a key requirement for olanzapine-induced weight gain in this paradigm and may not be mediated via alterations in the expression of the feeding-related hypothalamic neuropeptides examined in this study.