S
Sergey Kasparov
Researcher at University of Bristol
Publications - 132
Citations - 6933
Sergey Kasparov is an academic researcher from University of Bristol. The author has contributed to research in topics: Angiotensin II & Baroreceptor. The author has an hindex of 48, co-authored 128 publications receiving 6116 citations. Previous affiliations of Sergey Kasparov include Immanuel Kant Baltic Federal University.
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Journal ArticleDOI
Astrocytes control breathing through pH-dependent release of ATP
Alexander V. Gourine,Vitaliy Kasymov,Nephtali Marina,Feige Tang,M Figueiredo,S Lane,Anja G. Teschemacher,K. Michael Spyer,Karl Deisseroth,Sergey Kasparov +9 more
TL;DR: It is found that astrocytes of the brainstem chemoreceptor areas are highly chemosensitive and responded to physiological decreases in pH with vigorous elevations in intracellular Ca2+ and release of adenosine triphosphate (ATP) and induced adaptive increases in breathing.
Journal ArticleDOI
Lactate-mediated glia-neuronal signalling in the mammalian brain
Feige Tang,S Lane,Alla Korsak,Julian F. R. Paton,Alexander V. Gourine,Sergey Kasparov,Anja G. Teschemacher +6 more
TL;DR: Evidence is presented that L-lactate, independently of its caloric value, serves as an astrocytic signalling molecule in the locus coeruleus, the principal source of norepinephrine to the frontal brain and thus one of the most influential modulatory centers of the brain.
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Functional Oxygen Sensitivity of Astrocytes
Plamena R. Angelova,Vitaliy Kasymov,Isabel N. Christie,Shahriar SheikhBahaei,Egor A. Turovsky,Nephtali Marina,Alla Korsak,Jennifer D. Zwicker,Anja G. Teschemacher,Gareth L. Ackland,Gregory D. Funk,Sergey Kasparov,Andrey Y. Abramov,Alexander V. Gourine +13 more
TL;DR: In this article, it was shown that the hypoxia sensor of astrocytes resides in the mitochondria in which oxygen is consumed, leading to mitochondrial depolarization, production of free radicals, lipid peroxidation, activation of phospholipase C, IP3 receptors, and release of Ca(2+) from the intracellular stores.
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Cardioprotection evoked by remote ischaemic preconditioning is critically dependent on the activity of vagal pre-ganglionic neurones
Svetlana Mastitskaya,Nephtali Marina,Andrey Gourine,Michael P. Gilbey,K. Michael Spyer,Anja G. Teschemacher,Sergey Kasparov,Stefan Trapp,Gareth L. Ackland,Alexander V. Gourine +9 more
TL;DR: Data indicate a crucial dependence of RPc cardioprotection against ischaemia/reperfusion injury upon the activity of a distinct population of vagal pre-ganglionic neurones.
Journal ArticleDOI
Adenoviral vector demonstrates that angiotensin II-induced depression of the cardiac baroreflex is mediated by endothelial nitric oxide synthase in the nucleus tractus solitarii of the rat.
TL;DR: It is suggested that ANGII activates eNOS located in either neurones and/or endothelial cells to release NO, which acts selectively to depress the baroreflex.