Sergey Larionov

TL;DR: The results indicate that good agreement can be reached when the lesions are substantial, i.e., the lesions have reached isocortical structures, whereas when only mild subtle lesions were present the agreement was poorer, and it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers.

TL;DR: It is demonstrated that activated microglia and the microglial‐derived proinflammatory cytokine TNF can induce accumulation of the aggregation‐prone tau molecules in neurites via reactive oxygen species.

TL;DR: It is indicated that capillary CAA can result in capillary occlusion and is associated with cerebral blood flow disturbances providing an additional mechanism for toxic effects of the amyloid beta-protein in AD.

TL;DR: The results suggest that rigorous methodology and dichotomized assessment should be applied and that semiquantitative assessment can be recommended only for the cortical samples, and that there are limitations in the scoring of &agr;S-IR structures.

TL;DR: It is found that SIRPbeta1 was up-regulated and acted as a phagocytic receptor on microglia in amyloid precursor protein J20 (APP/J20) transgenic mice and in Alzheimer's disease (AD) patients.