S
Sergio Zanotti
Researcher at Cooper University Hospital
Publications - 18
Citations - 6306
Sergio Zanotti is an academic researcher from Cooper University Hospital. The author has contributed to research in topics: Septic shock & Sepsis. The author has an hindex of 9, co-authored 18 publications receiving 5691 citations. Previous affiliations of Sergio Zanotti include Rush University Medical Center.
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Journal ArticleDOI
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock.
Anand Kumar,Daniel Roberts,Kenneth E. Wood,Bruce Light,Joseph E. Parrillo,Satendra Sharma,Robert Suppes,Daniel Feinstein,Sergio Zanotti,Leo Taiberg,David A. Gurka,Aseem Kumar,Mary Cheang +12 more
TL;DR: Effective antimicrobial administration within the first hour of documented hypotension was associated with increased survival to hospital discharge in adult patients with septic shock.
Journal ArticleDOI
Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects.
Anand Kumar,Ramon Anel,Eugene Bunnell,Kalim Habet,Sergio Zanotti,Stephanie Marshall,Alex Neumann,Amjad Ali,Mary Cheang,Clifford J. Kavinsky,Joseph E. Parrillo +10 more
TL;DR: Normal healthy volunteers demonstrate a lack of correlation between initial central venous pressure/pulmonary artery occlusion pressure and both end-diastolic ventricular volume indexes and stroke volume index, suggesting a more universal phenomenon that includes normal subjects.
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Timing of vasopressor initiation and mortality in septic shock: a cohort study
Vance Beck,Dan Chateau,Gregory L. Bryson,Amarnath Pisipati,Sergio Zanotti,Joseph E. Parrillo,Anand Kumar +6 more
TL;DR: Marked delays in initiation of vasopressor/inotropic therapy are associated with a small increase in mortality risk in patients with septic shock, and this effect is driven by the group of patients with the longest delays.
Journal ArticleDOI
Cytokine modulation in sepsis and septic shock.
TL;DR: This review will examine clinical trials evaluating several strategies for blocking or attenuating TNF-α and IL-1β activity, and survey the current state of experimental therapies involving IL-10, transforming growth factor-β, granulocyte colony-stimulating factor and IFN-γ.
Journal ArticleDOI
Severe sepsis and septic shock: management and performance improvement.
TL;DR: The second part of the manuscript characterizes hospital based sepsis performance improvement programs and highlights the sepsi bundles from the Surviving Sepsis Campaign as a key component of such a program.