J
Joseph E. Parrillo
Researcher at Hackensack University Medical Center
Publications - 92
Citations - 6747
Joseph E. Parrillo is an academic researcher from Hackensack University Medical Center. The author has contributed to research in topics: Septic shock & Sepsis. The author has an hindex of 38, co-authored 92 publications receiving 5963 citations. Previous affiliations of Joseph E. Parrillo include Cooper Hospital & Rowan University.
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Journal ArticleDOI
Initiation of Inappropriate Antimicrobial Therapy Results in a Fivefold Reduction of Survival in Human Septic Shock
Anand Kumar,Anand Kumar,Paul Ellis,Yaseen M. Arabi,Dan Roberts,Bruce Light,Joseph E. Parrillo,Peter Dodek,Gordon Wood,Aseem Kumar,David Simon,Cheryl Peters,Muhammad Ahsan,Dan Chateau +13 more
TL;DR: Efforts to increase the frequency of the appropriateness of initial antimicrobial therapy must be central to efforts to reduce the mortality of patients with septic shock.
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Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: Relationship to hemodynamics, oxygen transport, and survival
Stephen Trzeciak,R. Phillip Dellinger,Joseph E. Parrillo,Massimiliano Guglielmi,Jasmeet Bajaj,Nicole L. Abate,Ryan C. Arnold,Susan Colilla,Sergio Zanotti,Steven M. Hollenberg +9 more
TL;DR: Early microcirculatory perfusion indices in severe sepsis and septic shock are more markedly impaired in nonsurvivors compared with survivors and with increasing severity of global cardiovascular dysfunction.
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Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis
Stephen Trzeciak,Jonathan V. McCoy,R. Phillip Dellinger,Ryan C. Arnold,Michael Rizzuto,Nicole L. Abate,Nathan I. Shapiro,Joseph E. Parrillo,Steven M. Hollenberg +8 more
TL;DR: Increased microcirculatory flow during resuscitation was associated with reduced organ failure at 24 h without substantial differences in global hemodynamics, and data support the hypothesis that targeting the microcirculation distinct from the macrocirculation could potentially improve organ failure in sepsis.
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Clinical review: Myocardial depression in sepsis and septic shock
TL;DR: It is now clear that cardiac dysfunction as evidenced by biventricular dilatation and reduced ejection fraction is present in most patients with severe sepsis and septic shock.
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Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy
Sean M. Bagshaw,Stephen E. Lapinsky,Sandra Dial,Yaseen M. Arabi,Peter Dodek,Gordon Wood,Paul Ellis,Jorge A. Guzman,John C. Marshall,Joseph E. Parrillo,Yoanna Skrobik,Anand Kumar +11 more
TL;DR: Survival was considerably lower for septic shock associated with early AKI, with increasing severity of AKi, and with increasing delays to appropriate antimicrobial therapy, as well as in both ICU and hospital.