Seyed Mehdi Sadat

TL;DR: This review describes polymeric carriers especially PLGA, chitosan, and PEI as vaccine delivery systems as well as natural polymers such as polysaccharides and synthetic polymers have demonstrated great potential to form vaccine nanoparticles.

TL;DR: Mice immunized with M720(+CpG) developed the highest HCVcp-specific titers of total IgG, IgG1, 2a, 2b, and that of IFN-gamma and IL-4 cytokines compared to all other groups, suggesting HCVCP formulated in M720 could induce balanced and strong Th1/Th2 responses with long-lived CD4(-)CD8(+) CTLs.

TL;DR: Current data indicates that lactobacilli supernatant encompasses components with neutralizing activity against HIV and HSV and it would be a determinant factor for viral diseases transmission and promising lead for anti-viral probiotic design.

TL;DR: Findings showed that the use of Tat (PTD)-Nef antigen in prime-boost strategy along with Gp96 adjuvant and Cady-2 CPP may have practical implications for developing HIV-1 vaccine in large animal model.

TL;DR: HIV-1 VLPs combined with N. meningitidis B OMVs seem to be a promising approach in vaccine development against HIV-1, and results of cytokine and ELISpot assays showed the capability of VLP+OMV immunogen for effective induction of IFN-gamma; and IL4 secreting cells and suggested the promotion of Th1-oriented response that was evidenced with the increasedIFN-γ/IL4 secretion ratio.