Seyed Moghimi

TL;DR: It is demonstrated that this strategy to minimize the removal by macrophages of the reticuloendothelial system by covering their surface with hydrophilic polymers may not necessarily prolong the circulatory half-life of drug carriers in all animal models.

TL;DR: It is demonstrated that organ-specific receptors, opsonin activities and plasma dysopsonins regulate the in vivo clearance of particulate materials from the circulation by modulating particle clearance by effectively blocking opsonization but still allowing for Dysopsonization.

TL;DR: A multiplicity of physicochemical and physiopathological factors which influence the clearance kinetics and tissue distribution of liposomes administered into the circulation are addressed.

TL;DR: It is demonstrated that the macrophages of the red-pulp can effectively phagocytose the filtered poloxamine-coated microspheres 24 h post-administration, which could be the result of either the loss of the surface absorbed polxamine, and hence the steric barrier, or 'neutralization' of the effect of the anti-phagocytic material poloxamines-908 within the spleen.

TL;DR: Observations suggest that a lymphatic delivery composition based on polymer‐coated particles will be advantageous for many applications in clinical and experimental medicine.