Journal ArticleDOI
Serum-mediated recognition of liposomes by phagocytic cells of the reticuloendothelial system - The concept of tissue specificity.
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A multiplicity of physicochemical and physiopathological factors which influence the clearance kinetics and tissue distribution of liposomes administered into the circulation are addressed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 1998-06-08. It has received 245 citations till now. The article focuses on the topics: Liposome & Mononuclear phagocyte system.read more
Citations
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Principles of nanoparticle design for overcoming biological barriers to drug delivery
TL;DR: By successively addressing each of the biological barriers that a particle encounters upon intravenous administration, innovative design features can be rationally incorporated that will create a new generation of nanotherapeutics, realizing a paradigmatic shift in nanoparticle-based drug delivery.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Strategies in the design of nanoparticles for therapeutic applications
TL;DR: This Review focuses on recent progress important for the rational design of such nanoparticles and discusses the challenges to realizing the potential of nanoparticles.
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Magnetic nanoparticle design for medical diagnosis and therapy
TL;DR: A special emphasis is made on magnetic nanoparticle requirements from a physical viewpoint, the factors affecting their biodistribution and the solutions envisaged for enhancing their half-life in the blood compartment and targeting tumour cells.
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Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy.
Parag Aggarwal,Jennifer B. Hall,Christopher B. McLeland,Marina A. Dobrovolskaia,Scott E. McNeil +4 more
TL;DR: Recent research on nanoparticle physicochemical properties important for protein binding, techniques for isolation and identification of nanoparticle-bound proteins, and how these proteins can influence particle biodistribution and biocompatibility are reviewed.
References
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Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.
TL;DR: By selective changes in lipid composition, up to a 60-fold increase in the fraction of recovered dose present in blood 24 hr after i.v. injection is achieved, which has considerable therapeutic potential in cancer for increasing the concentration of cytotoxic agents in tumors while minimizing the likelihood of toxicity to the reticuloendothelial system.
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Sterically stabilized liposomes
Martin C. Woodle,Danilo D. Lasic +1 more
TL;DR: The structure-function relationship of PEG-derivatized phosphatidylethanolamine (PEG-PE) has been examined by measurement of blood lifetime and tissue distribution in both mice and rats and Steric stabilization has been proposed as a theoretical basis for the results.
Journal Article
Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3.
A P Robinson,T M White,D W Mason +2 more
TL;DR: Membrane molecules with similar biochemical and functional properties to MRC OX-42 antigen have been identified in mouse and man as the receptors for iC3b, and it is probable that MRCOX- 42 antibody recognizes the rat homologue of the receptors in these other species.
Journal Article
Fate and behavior of liposomes in vivo: a review of controlling factors.
TL;DR: Results of recent studies are brought together which describe how liposomal stability and clearance in vivo are controlled by the architecture of the vesicles themselves which in turn, via interaction with humoral factors, controls the fate in terms of tissue distribution of the carrier and its contents.
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Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles.
TL;DR: Preformed liposomes which quantitatively retain aqueous markers were covalenty coupled via dipalmitoylphosphatidyl-ethanolamine, to the hydrophilic polymer, monomethoxypoly(ethylene glycol) (MPEG 5000), and it is suggested that the polymer acts as a surface barrier to plasma factors which otherwise bind to liposome in the blood and accelerate vesicle removal.