S
Seyyed Abolghasem Ghadami
Researcher at Alzahra University
Publications - 25
Citations - 295
Seyyed Abolghasem Ghadami is an academic researcher from Alzahra University. The author has contributed to research in topics: Thioflavin & Amyloid. The author has an hindex of 8, co-authored 22 publications receiving 226 citations. Previous affiliations of Seyyed Abolghasem Ghadami include Kermanshah University of Medical Sciences & Razi University.
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Journal ArticleDOI
Comparative spectroscopic studies on drug binding characteristics and protein surface hydrophobicity of native and modified forms of bovine serum albumin: possible relevance to change in protein structure/function upon non-enzymatic glycation.
Reza Khodarahmi,Seyyed Arash Karimi,Mohammad Reza Ashrafi Kooshk,Mohammad Reza Ashrafi Kooshk,Seyyed Abolghasem Ghadami,Seyyed Abolghasem Ghadami,Sirous Ghobadi,Mojtaba Amani +7 more
TL;DR: Analysis of the quenching and thermodynamic parameters indicated that intermolecular interactions between drug and albumin may change upon protein modification, and some conformational changes of interacting side chains in subdomain IIA binding site were suggested.
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Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers.
Seyyed Abolghasem Ghadami,Sean Chia,Francesco Simone Ruggeri,Georg Meisl,Francesco Bemporad,Johnny Habchi,Roberta Cascella,Christopher M. Dobson,Michele Vendruscolo,Tuomas P. J. Knowles,Fabrizio Chiti +10 more
TL;DR: Biophysical methods found that transthyretin was found to change some aspects of its overall structure following such interactions with Aβ40 oligomers, as well as with oligomers of Aβ42, while maintaining its overall topology.
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Comparative Spectroscopic Studies on Curcumin Stabilization by Association to Bovine Serum Albumin and Casein: A Perspective on Drug-Delivery Application
Mohammad Mostafa Nadi,Mohammad Reza Ashrafi Kooshk,Kamran Mansouri,Seyyed Abolghasem Ghadami,Mojtaba Amani,Sirous Ghobadi,Reza Khodarahmi +6 more
TL;DR: It appears from thermodynamic analyses that in “protein-curcumin” systems, water molecules are excluded from the vicinity of curcumin, so that some of them may provide novel tools to increase both food quality and the bioavailability ofCurcumin as a health promoting agent.
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Spectroscopic and molecular modeling studies on binding of dorzolamide to bovine and human carbonic anhydrase II.
TL;DR: It is concluded that DZA binds stronger to hCA II active site cavity compared to bCA II, and the possible binding mode revealed by molecular docking and molecular dynamic studies.
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Amyloid fibril formation by native and modified bovine β-lactoglobulins proceeds through unfolded form of proteins: a comparative study.
TL;DR: The results clearly demonstrated that the stability of modified β-lg is markedly reduced, compared to the native one and highlighted the critical role of protein stability and elucidated the underlying role of hydrophobic/electrostatic interactions in lactoglobulin-based experimental system.