Showing papers in "Biomacromolecules in 2020"

TL;DR: This review will present the fundamentals of ECM, cover the chemical and structural features of the scaffolds used to generate ECM mimics, discuss the nature of the signaling biomolecules required and exploited to generate bioresponsive cell microenvironments able to induce a specific cell fate, and highlights the syn-thetic strategies involved to create functional 3D ECm mimics.

TL;DR: The results demonstrated the better wound healing effect of these multiantibacterial injectable conductive hydrogel in infectious skin tissue defect repair, indicating their great potential for infected wound healing.

TL;DR: This study demonstrates the production, characterization, and characterization of silver nanoparticles using aqueous curcumin:hydroxypropyl-β-cyclodextrin complex and loading them into bacterial cellulose hydrogel with moist wound-healing properties that exhibited antimicrobial activity against three common wound-infecting pathogenic microbes.

TL;DR: The hydrogels with intrinsic or stimuli-triggered bactericidal properties and others that serve as vehicles for loading antibacterial agents without synthetic antibiotics are summarized in the current review.

TL;DR: A comprehensive overview of the fundamentals of emulsion polymerization and related processes is presented with the object of providing theoretical and practical understanding to researchers considering use of these methods for synthesis of polymer colloids across a wide range of applications.

TL;DR: This review will highlight the key factors in design, development, and improved performance of these vesicles for macromolecular delivery and the recent progress made towards pre-clinical application.

TL;DR: This work generates two and three coexisting macromolecule-rich liquid compartments by complex coacervation based on ion pairing in mixtures that contain two or three polyanions together with one, two, or threepolycations, showing the ease of generating multiphase coacervates and the ability to tune their partitioning properties via the polyelectrolyte sharing inherent to multiphases complex coACervate systems.

TL;DR: A deep understanding of β-glucans with triple-helix chain conformation is essential for the successful applications of the natural medicines and biologics for a sustainable world.

TL;DR: Recent advancements to further the understanding of interactions between biomolecules and zwitterionic moieties are summarized and the molecular interactions between these molecules and biomolecule as determined by both experimental and theoretical studies are discussed.

TL;DR: The effect of molecular lignin structure on thermomechanical properties was analyzed, finding significant differences between the rigid guaiacyl units in spruce lignIn compared with sinapyl units in eucalyptus lign in.

TL;DR: The recent advances in developing hydrogel-based wound dressings as well as their adhesion mechanism are summarized and the progress prospects over the coming years were covered.

TL;DR: This review aims to give the latest advances of magnetic hydrogels based on natural polymers such as polysaccharide, protein and DNA in drug delivery systems.

TL;DR: The novel injectable, self-healing and sensitive pH-responsive hydrogel serves as a promising candidate as localized drug carriers with controlled delivery capability triggered by acidosis, holding great promise for cancer therapy, wound healing and infection treatment.

TL;DR: The study investigates the chemical recycling and the solvent resistance of these vitrimers-like materials that have a high biobased carbon content, from 80 to 91%, with potential application in coating or composite materials in automotive sector.

TL;DR: This mini-review of Silk materials, including native silk fibers and a broad spectrum of regenerated silk materials, investigated in vitro and in vivo to demonstrate degradation by proteolytic enzymes highlights some key challenges and potential directions toward the future study of the degradation of silk materials.

TL;DR: The results demonstrate that nanocomposite CNF-alginate-CLP scaffolds have high potential in soft-tissue engineering and regenerative-medicine applications.

TL;DR: This Perspective will introduce polyampholytes as emerging macromolecular cryoprotective agents and demonstrate they have the potential to impact a range of fields from cell-based therapies to basic cell biology and may be able to improve, or replace, current solvent-based cryoprotsective agents.

TL;DR: Different O2 generating sources, including hydrogen peroxide, sodium percarbonate, calcium peroxide and magnesium peroxide are presented, and types of carriers and relevant methods of fabricating O 2 generating systems are covered.

TL;DR: The lignin NCs are of high interest as biodegradable delivery vehicles to be applied by trunk injection against the devastating fungal disease Esca but might also be promising against other fungal plant diseases.

TL;DR: The dual supramolecular hydrogel developed in this work with remarkable thermoresponsive properties might have potential for sustained anticancer drug delivery with enhanced therapeutic effect in multidrug resistant cancer cells.

TL;DR: Paper based BC-Ch nanocomposites combined the physical properties of BC paper and the antimicrobial, antibiofilm and antioxidant activity of chitosan to inhibit the formation of biofilms on their surface.

TL;DR: This Perspective presents a thorough overview of chitin-related materials research with an analytical focus on nanocomposites and nanopapers, highlighting the use of fungal chit in that represents several advantages over the more popular crustacean sources, particularly in terms of nanofiber isolation from the native matrix.

TL;DR: In vivo anti-inflammatory studies revealed that nanoparticles exhibit enhanced efficacy in alleviating inflammation-related symptoms in mouse colitis model, suggesting that the core-shell nanoparticles presented here can be exploited as efficient colon-targeted drug delivery systems for UC therapy.

TL;DR: The results demonstrate that this biocompatible and biodegradable CS-HA/hmCS lactate hydrogel has great promise for sutureless closure of surgical incisions and promote wound healing.

TL;DR: The proposed self-healing collagen-based hydrogel would not only protect cells during injection but also fit into the irregular cartilage defect, thus holds the promise in delivering MSCs for cartilage regeneration through minimally invasive procedures.

TL;DR: A two-step additive manufacturing process to fabricate robust protein-based constructs using a commercially available laser-based SLA printer and is expected to be compatible with other vat photopolymerization techniques including digital light projection (DLP) and continuous liquid interface production (CLIP).

TL;DR: This new class of boronate ester cross-linked hydrogel provides promising future for diverse biomedical applications and exhibited excellent self-healing and injectability behaviors in aqueous conditions and was found to be responsive to pH.

TL;DR: The biocompatible pH responsive photodynamic antimicrobial hydrogels developed herein could be potentially applicable in controlled drug delivery through the construction of wound dressings, as well as for developing antifungal, antibacterial or antiviral nanocoatings.

TL;DR: In vivo results prove that GelPV-DOX-DBNP exhibited a markedly enhanced chemo-photothermal synergistic therapy for 4T1 tumor model mice, compared to alone chemotherapy or PTT.

TL;DR: A series of bio-inspired photo-stable and biocompatible polydopamine-grafted lignin (AL-PDA) with strong bioadhesion, synthesized through free radical addition of dopamine (DA) and alkali lign in order to form nano-capsules for sunscreen formulating.