S
Shalesh Kaushal
Researcher at University of Massachusetts Medical School
Publications - 84
Citations - 6411
Shalesh Kaushal is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Retinal degeneration & Rhodopsin. The author has an hindex of 33, co-authored 84 publications receiving 5981 citations. Previous affiliations of Shalesh Kaushal include University of Florida & University of Massachusetts Amherst.
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Journal ArticleDOI
Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial
William W. Hauswirth,Tomas S. Aleman,Shalesh Kaushal,Artur V. Cideciyan,Sharon B. Schwartz,Lili Wang,Thomas J. Conlon,Sanford L. Boye,Terence R. Flotte,Barry J. Byrne,Samuel G. Jacobson +10 more
TL;DR: A recombinant adeno-associated virus serotype 2 vector, altered to carry the human RPE65 gene (rAAV2-CBSB-hRPE65) restored vision in animal models with R PE65 deficiency, and Comparisons are drawn between the present work and two other studies of ocular gene therapy for RPE 65-LCA that were carried out contemporaneously and reported.
Journal ArticleDOI
Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics
Artur V. Cideciyan,Tomas S. Aleman,Sanford L. Boye,Sharon B. Schwartz,Shalesh Kaushal,Alejandro J. Roman,Jijing Pang,Alexander Sumaroka,Elizabeth A. M. Windsor,James M. Wilson,Terence R. Flotte,Gerald A. Fishman,Elise Heon,Edwin M. Stone,Barry J. Byrne,Samuel G. Jacobson,William W. Hauswirth +16 more
TL;DR: It is found that the intervention could overcome nearly all of the loss of light sensitivity resulting from the biochemical blockade, however, this reconstituted retinoid cycle was not completely normal.
Journal ArticleDOI
Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years
Samuel G. Jacobson,Artur V. Cideciyan,R. Ratnakaram,Elise Héon,Sharon B. Schwartz,Alejandro J. Roman,Marc C. Peden,Tomas S. Aleman,Sanford L. Boye,Alexander Sumaroka,Thomas J. Conlon,Roberto Calcedo,Jijing Pang,Kirsten E. Erger,Melani B. Olivares,Cristina L. Mullins,Malgorzata Swider,Shalesh Kaushal,William J. Feuer,Alessandro Iannaccone,Gerald A. Fishman,Edwin M. Stone,Barry J. Byrne,William W. Hauswirth +23 more
TL;DR: Gene therapy for Leber congenital amaurosis caused by RPE65 mutations is sufficiently safe and substantially efficacious in the extrafoveal retina and the results point to specific treatment strategies for subsequent phases.
Journal ArticleDOI
Human RPE65 Gene Therapy for Leber Congenital Amaurosis: Persistence of Early Visual Improvements and Safety at 1 Year
Artur V. Cideciyan,William W. Hauswirth,Tomas S. Aleman,Shalesh Kaushal,Sharon B. Schwartz,Sanford L. Boye,Elizabeth A. M. Windsor,Thomas J. Conlon,Alexander Sumaroka,Jijing Pang,Alejandro J. Roman,Barry J. Byrne,Samuel G. Jacobson +12 more
TL;DR: The safety and efficacy of human retinal gene transfer with rAAV2-RPE65 vector extends to at least 1 year posttreatment, and the remarkable improvements in visual sensitivity reported by 3 months were unchanged at 12 months.
Journal ArticleDOI
Pharmacological Chaperone-mediated in Vivo Folding and Stabilization of the P23H-opsin Mutant Associated with Autosomal Dominant Retinitis Pigmentosa
Syed Mohammed Noorwez,Vladimir A. Kuksa,Yoshikazu Imanishi,Li Zhu,Slawomir Filipek,Krzysztof Palczewski,Shalesh Kaushal +6 more
TL;DR: In this paper, a pharmacological chaperone, 11-cis-7-ring retinal, was used to induce the in vivo folding of P23H-opsin and the rescued protein formed pigment, acquired mature glycosylation, and was transported to the cell surface.