Yoshikazu Imanishi

TL;DR: The histological analysis and electron microscopy of the retina for 6–8-week-old Lrat-/- mice revealed that the rod outer segments are ∼35% shorter than those of Lrat+/+ mice, whereas other neuronal layers appear normal andScotopic and photopic electroretinograms as well as pupillary constriction analyses revealed that rod and cone visual functions are severely attenuated at an early age.

TL;DR: Observations indicate that CaBP4 is important for normal synaptic function, probably through regulation of Ca2+ influx and neurotransmitter release in photoreceptor synaptic terminals.

TL;DR: In this paper, a pharmacological chaperone, 11-cis-7-ring retinal, was used to induce the in vivo folding of P23H-opsin and the rescued protein formed pigment, acquired mature glycosylation, and was transported to the cell surface.

TL;DR: Three enzymes from a novel subfamily of four retinol dehydrogenases (RDH11–14) that display dual-substrate specificity are described, uniquely metabolizing all-trans- andcis-retinols with C15 pro-Rspecificity.

TL;DR: Results indicate that RESTs located close to the RPE plasma membrane are essential components in 11-cis-retinal production, and are absent in the eyes of Lrat −/− mice deficient in retinyl ester synthesis.