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Artur V. Cideciyan
Researcher at University of Pennsylvania
Publications - 284
Citations - 23109
Artur V. Cideciyan is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Retinal degeneration & Retina. The author has an hindex of 82, co-authored 275 publications receiving 20805 citations. Previous affiliations of Artur V. Cideciyan include University of Florida & Scheie Eye Institute.
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Journal ArticleDOI
Gene therapy restores vision in a canine model of childhood blindness.
Gregory M. Acland,Gustavo D. Aguirre,Jharna Ray,Qi Zhang,Tomas S. Aleman,Artur V. Cideciyan,Susan E. Pearce-Kelling,Vibha Anand,Yong Zeng,Albert M. Maguire,Samuel G. Jacobson,William W. Hauswirth,Jean Bennett +12 more
TL;DR: The results indicate that visual function was restored in this large animal model of childhood blindness, and gene therapy directed at photoreceptors and RPE in a large-animal model of human disease has not been reported.
Journal ArticleDOI
Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial
William W. Hauswirth,Tomas S. Aleman,Shalesh Kaushal,Artur V. Cideciyan,Sharon B. Schwartz,Lili Wang,Thomas J. Conlon,Sanford L. Boye,Terence R. Flotte,Barry J. Byrne,Samuel G. Jacobson +10 more
TL;DR: A recombinant adeno-associated virus serotype 2 vector, altered to carry the human RPE65 gene (rAAV2-CBSB-hRPE65) restored vision in animal models with R PE65 deficiency, and Comparisons are drawn between the present work and two other studies of ocular gene therapy for RPE 65-LCA that were carried out contemporaneously and reported.
Journal ArticleDOI
Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics
Artur V. Cideciyan,Tomas S. Aleman,Sanford L. Boye,Sharon B. Schwartz,Shalesh Kaushal,Alejandro J. Roman,Jijing Pang,Alexander Sumaroka,Elizabeth A. M. Windsor,James M. Wilson,Terence R. Flotte,Gerald A. Fishman,Elise Heon,Edwin M. Stone,Barry J. Byrne,Samuel G. Jacobson,William W. Hauswirth +16 more
TL;DR: It is found that the intervention could overcome nearly all of the loss of light sensitivity resulting from the biochemical blockade, however, this reconstituted retinoid cycle was not completely normal.
Journal ArticleDOI
Interim Results from the International Trial of Second Sight's Visual Prosthesis
Mark S. Humayun,Jessy D. Dorn,Lyndon da Cruz,Gislin Dagnelie,José-Alain Sahel,Paulo E. Stanga,Artur V. Cideciyan,Jacque L. Duncan,Dean Eliott,Eugene Filley,Allen C. Ho,Arturo Santos,Avinoam B. Safran,Aries Arditi,Lucian V. Del Priore,Lucian V. Del Priore,Robert J. Greenberg +16 more
TL;DR: The long-term safety results of Second Sight's retinal prosthesis system are acceptable, and most subjects with profound visual loss perform better on visual tasks with system than without it.
Journal ArticleDOI
Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years
Samuel G. Jacobson,Artur V. Cideciyan,R. Ratnakaram,Elise Héon,Sharon B. Schwartz,Alejandro J. Roman,Marc C. Peden,Tomas S. Aleman,Sanford L. Boye,Alexander Sumaroka,Thomas J. Conlon,Roberto Calcedo,Jijing Pang,Kirsten E. Erger,Melani B. Olivares,Cristina L. Mullins,Malgorzata Swider,Shalesh Kaushal,William J. Feuer,Alessandro Iannaccone,Gerald A. Fishman,Edwin M. Stone,Barry J. Byrne,William W. Hauswirth +23 more
TL;DR: Gene therapy for Leber congenital amaurosis caused by RPE65 mutations is sufficiently safe and substantially efficacious in the extrafoveal retina and the results point to specific treatment strategies for subsequent phases.