Shang Li

TL;DR: It is revealed, for the first time, that calycosin acts as a selective estrogen receptor modulator (SERM) to promote angiogenesis, at least in part through VEGF-VEGFR2 and MAPK signaling pathways.

TL;DR: The structural analysis shows that two active compounds present novel scaffolds and are potential leads for the development of novel anti-cancer drugs and the pharmacological effect of the two ROCK1 inhibitors with novel scaffolding on atorvastatin-induced cerebral hemorrhage was evaluated by using zebrafish model.

TL;DR: The advantages of the zebrafish model for evaluating drug metabolism and the mode of pharmacological action with the emerging omics approaches are discussed.

TL;DR: The results suggest that AS-IV exerts potential pro-angiogenic effects in vitro and in vivo, and that its pro-ANGiogenic activity probably involves both VEGF- and Akt-dependent signaling pathways.

TL;DR: The underlying mechanisms that formononetin produced proangiogenesis effects through an ERα-enhanced ROCK-II signaling pathways are elucidated and the enigmatic underlying mechanisms of phytoestrogenic compounds in the promotion of angiogenesis in relation to ERα and ROCK interaction in endothelial cells and their relationship with actin assembly and cell migration are expanded.