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Deepa Alex
Researcher at University of Macau
Publications - 12
Citations - 591
Deepa Alex is an academic researcher from University of Macau. The author has contributed to research in topics: Angiogenesis & Zebrafish. The author has an hindex of 9, co-authored 9 publications receiving 545 citations. Previous affiliations of Deepa Alex include Hong Kong University of Science and Technology & University of Hong Kong.
Papers
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Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC.
Jing Yan Tang,Shang Li,Zhen Hua Li,Zai Jun Zhang,Guang Hu,Lorita Chi Veng Cheang,Deepa Alex,Maggie Pui Man Hoi,Yiu Wa Kwan,Shun Wan Chan,George P.H. Leung,Simon Ming-Yuen Lee +11 more
TL;DR: It is revealed, for the first time, that calycosin acts as a selective estrogen receptor modulator (SERM) to promote angiogenesis, at least in part through VEGF-VEGFR2 and MAPK signaling pathways.
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In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent.
In Kei Lam,Deepa Alex,Youhua Wang,Ping Liu,Ai-Lin Liu,Ai-Lin Liu,Guanhua Du,Simon Ming-Yuen Lee +7 more
TL;DR: In vivo structure-activity relationship (SAR) analysis indicated that a flavonoid with a methoxylated group at the C3' position offers a stronger antiangiogenesis activity, whereas the absence of a meth Oxylated Group at theC8 position offers lower lethal toxicity in addition to enhancing the antiang iogenesis activity.
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Expression of Brassica juncea 3-hydroxy-3-methylglutaryl CoA synthase is developmentally regulated and stress-responsive.
TL;DR: HMGS assays confirmed that Escherichia coli-expressed recombinant BjHMGS1 shows HMGS activity that is inhibited by F244, a specific inhibitor of HMGS, suggesting that, like HMGR, HMGS is involved in defence.
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Inhibition of TNF-α-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4'-trimethoxystilbene.
Yan-Hui Deng,Deepa Alex,He-Qing Huang,Nan Wang,Nan Yu,Yitao Wang,George P.H. Leung,Simon Ming-Yuen Lee +7 more
TL;DR: It is shown, for the first time, that its derivative trans‐3,5,4′‐trimethoxystilbene (TMS) may be a more potent anti‐inflammatory agent than resveratrol.
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Nobiletin, a polymethoxylated flavonoid from citrus, shows anti‐angiogenic activity in a zebrafish in vivo model and HUVEC in vitro model
TL;DR: Nobiletin, a polymethoxylated flavonoid from citrus fruits, showed anti‐angiogenic activity in both in vivo and in vitro in human umbilical vein endothelial cells (HUVECs), and nobiletin has a great potential for future research and development as a cytostatic anti‐proliferative agent.