Shanna L. Resendez

TL;DR: A new constrained matrix factorization approach to accurately separate the background and then demix and denoise the neuronal signals of interest is described, which substantially improved the quality of extracted cellular signals and detected more well-isolated neural signals, especially in noisy data regimes.

TL;DR: It is shown that selective optogenetic stimulation of a molecularly defined subset of LH GABAergic (Vgat-expressing) neurons enhances both appetitive and consummatory behaviors, whereas genetic ablation of these neurons reduced these phenotypes.

TL;DR: In vivo two-photon calcium imaging is used to monitor the activity of dorsomedial prefrontal neurons in mice during an appetitive Pavlovian conditioning task to show how prefrontal circuitry can dynamically control reward-seeking behaviour through the opposing activities of projection-specific cell populations.

TL;DR: These limitations can be circumvented by using miniature, integrated microscopes in conjunction with an implantable microendoscopic lens to guide light into and out of the brain, thus permitting optical access to deep brain (or superficial) neural ensembles during naturalistic behaviors.

TL;DR: It is demonstrated that blockade of κ-opioid receptors within the nucleus accumbens (NAc) shell abolishes selective aggression in both sexes, but blockade of these receptorswithin the NAc core enhances this behavior specifically in females, providing the first comprehensive characterization of λ- and μ-opIOid receptors in the prairie vole brain.