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Shaolin Shi
Researcher at Albert Einstein College of Medicine
Publications - 23
Citations - 1426
Shaolin Shi is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Notch signaling pathway & Medicine. The author has an hindex of 14, co-authored 17 publications receiving 1345 citations. Previous affiliations of Shaolin Shi include University of California, San Diego & Yeshiva University.
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Journal ArticleDOI
Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways.
Shaolin Shi,Pamela Stanley +1 more
TL;DR: It is shown that mouse embryos lacking protein O-fucosyltransferase 1 die at midgestation with severe defects in somitogenesis, vasculogenesis, cardiogenesis, and neurogenesis, and the phenotype is similar to that of embryos lacking downstream effectors of all Notch signaling pathways such as presenilins or RBP-Jκ.
Journal ArticleDOI
Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase.
Yang Wang,Li Shao,Shaolin Shi,Reed J. Harris,Michael W. Spellman,Pamela Stanley,Robert S. Haltiwanger +6 more
TL;DR: The isolation of a cDNA that encodes human O-FucT-1 is reported, which contains an open reading frame encoding a protein of 388 amino acids with a predicted N-terminal transmembrane sequence typical of a type II membrane orientation.
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Roles of Pofut1 and O-Fucose in Mammalian Notch Signaling
Mark Stahl,Kazuhide Uemura,Kazuhide Uemura,Changhui Ge,Shaolin Shi,Shaolin Shi,Yuko Tashima,Pamela Stanley +7 more
TL;DR: Mammalian Notch receptors contain 29–36 epidermal growth factor-like repeats that may be modified by protein O-fucosyltransferase 1 (Pofut1), an essential component of the canonical Notch signaling pathway, but, in contrast to Drosophila, P ofut1 is not required for stable cell surface expression of Notch.
Journal ArticleDOI
The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy
Krista D. Buono,Gertraud W. Robinson,Cyril Martin,Shaolin Shi,Pamela Stanley,Kenji Tanigaki,Tasuku Honjo,Lothar Hennighausen +7 more
TL;DR: It is proposed that the Notch-RBP-J pathway regulates alveolar development during pregnancy by maintaining luminal cell fate and preventing uncontrolled basal cell proliferation.
Journal ArticleDOI
Inactivation of the Mgat1 gene in oocytes impairs oogenesis, but embryos lacking complex and hybrid N-glycans develop and implant.
Shaolin Shi,Suzannah A. Williams,Antti Seppo,Henry Kurniawan,Wei Chen,Z Y Ye,Jamey D. Marth,Pamela Stanley +7 more
TL;DR: In this paper, the Mgat1 gene in oocytes was deleted by using a ZP3Cre recombinase transgene to identify roles for complex and hybrid N-glycans in oogenesis and preimplantation development.