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Yong Guo Zhang
Researcher at University of Illinois at Chicago
Publications - 33
Citations - 2550
Yong Guo Zhang is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Intestinal mucosa & Calcitriol receptor. The author has an hindex of 23, co-authored 33 publications receiving 2088 citations. Previous affiliations of Yong Guo Zhang include University of Rochester & Rush University.
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Journal ArticleDOI
Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis
Shaoping Wu,Yong Guo Zhang,Rong Lu,Yinglin Xia,David Zhou,Elaine O. Petrof,Erika C. Claud,Di Chen,Eugene B. Chang,Geert Carmeliet,Jun Sun +10 more
TL;DR: Fundamental relationship between VDR, autophagy and gut microbial assemblage that is essential for maintaining intestinal homeostasis, but also in contributing to the pathophysiology of IBD is demonstrated.
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Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease
Ali Keshavarzian,Ali Banan,Ashkan Farhadi,Srinadh Komanduri,Ece Mutlu,Yong Guo Zhang,Jeremy Z. Fields +6 more
TL;DR: Oxidant levels increase in IBD along with oxidation of tissue and cytoskeletal proteins, and marked actin oxidation—which appears to result from cumulative oxidative damage—was only seen in inflamed mucosa, suggesting that oxidant induced cytOSkeletal disruption is required for tissue injury, mucosal disruption, and IBD flare up.
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Lack of Vitamin D Receptor Causes Dysbiosis and Changes the Functions of the Murine Intestinal Microbiome
TL;DR: Several important pathways, such as nucleotide-binding oligomerization domain-like receptor, affected by VDR status are identified, including amino acid, carbohydrate, and fatty acid synthesis and metabolism, detoxification, infections, signal transduction, and cancer and other diseases.
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Salmonella‐infected crypt‐derived intestinal organoid culture system for host–bacterial interactions
TL;DR: It is demonstrated that the Salmonella‐infected organoid culture system is a new experimental model suitable for studying host–bacterial interactions and the inflammatory responses through activation of the NF‐κB pathway in the organoids.
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Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model
TL;DR: A potential novel role of the intestinal epithelium and microbiome in the progression of ALS is suggested and principal coordinate analysis indicated a difference in fecal microbial communities between ALS and wild‐type mice.