S
Sharad Kumar
Researcher at University of South Australia
Publications - 315
Citations - 48227
Sharad Kumar is an academic researcher from University of South Australia. The author has contributed to research in topics: Caspase & Programmed cell death. The author has an hindex of 89, co-authored 296 publications receiving 40118 citations. Previous affiliations of Sharad Kumar include Australian National University & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
Regulation of Neuronal Voltage-gated Sodium Channels by the Ubiquitin-Protein Ligases Nedd4 and Nedd4-2
TL;DR: It is shown that the carboxyl termini fusion proteins of one central nervous system and one peripheral nervous system-derived Na+ channel are readily ubiquitinated by Nedd4-2, and these channels have conserved WW domain binding specificity.
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Prodomain-dependent nuclear localization of the caspase-2 (Nedd2) precursor. A novel function for a caspase prodomain.
TL;DR: The results suggest that, in addition to roles in dimerization and recruitment through adaptors, the caspase-2 prodomain has a novel function in nuclear transport.
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The Apical Caspase dronc Governs Programmed and Unprogrammed Cell Death in Drosophila
Su Kit Chew,Fatih Akdemir,Po Chen,Wan Jin Lu,Kathryn Mills,Tasman Daish,Sharad Kumar,Antony Rodriguez,John M. Abrams +8 more
TL;DR: Findings establish dronc as an essential regulator of cell number in development and illustrate broad requirements for this apical caspase in adaptive responses during stress-induced apoptosis.
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An Essential Role for the Caspase Dronc in Developmentally Programmed Cell Death in Drosophila
Leonie M. Quinn,Loretta Dorstyn,Kathryn Mills,Paul A. Colussi,Po Chen,Michelle Coombe,John M. Abrams,Sharad Kumar,Helena E. Richardson +8 more
TL;DR: E ectopic expression of dronc in the developing fly eye leads to increased cell death and an ablated eye phenotype that can be suppressed by halving the dosage of the genes in the H99complex (reaper, hid, and grim) and enhanced by mutations in diap1.
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Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins.
TL;DR: Recent insights into how accessory and adaptor proteins modulate the activities of Nedd4 family members are discussed, including recruitment of novel substrates, alteration of subcellular localisation and effects on ubiquitination are discussed.