Sharad Kumar

TL;DR: The present work shows that the factor‐dependent cell line FDC‐P1 expressing mouse antisense Nedd2 mRNA, exhibits significant inhibition of cell death upon removal of the cytokines, thus providing evidence for a direct role of Nedd 2 in mediating apoptosis.

TL;DR: This work shows, for the first time, that a signature protein of caveolae, caveolin-1 (Cav-1), down-regulates the activity and membrane surface expression of the epithelial Na+ channel, and suggests that Cav-1 inhibits the activity of ENaC by decreasing expression of EN aC at the cell membrane via a mechanism that involves the promotion of Nedd4-2-dependent internalization of the channel.

TL;DR: It is demonstrated that endogenous RAIDD is mostly localized in the cytoplasm and to some extent in the nucleus, and evidence that RAIDD-CARD oligomerization may be regulated by intramolecular folding of the RAIDD molecule is presented.

TL;DR: It is proposed that the predicted protein, named DRG, represents an evolutionarily conserved novel class of GTP-binding protein which may play an important role in cell physiology.

TL;DR: It is demonstrated here that during CTL-mediated cytolysis the catalytic subunit of DNA- dependent protein kinase (DNA-PKcs), an enzyme implicated in the repair of double strand breaks in DNA, is specifically cleaved by an interleukin (IL)-1 beta-converting enzyme (ICE)-like protease.