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Sharon A. Clark
Researcher at University of Calgary
Publications - 10
Citations - 2016
Sharon A. Clark is an academic researcher from University of Calgary. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 8, co-authored 9 publications receiving 1802 citations.
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Journal ArticleDOI
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
Daniel A. Muruve,Virginie Pétrilli,Anne K. Zaiss,Lindsay R. White,Sharon A. Clark,P. Joel Ross,Robin J. Parks,Jürg Tschopp +7 more
TL;DR: It is shown that internalized adenoviral DNA induces maturation of pro-interleukin-1β in macrophages, which is dependent on NALP3 and ASC, components of the innate cytosolic molecular complex termed the inflammasome, which strengthens their central role in innate immunity.
Journal ArticleDOI
The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD
Akosua Vilaysane,Justin Chun,Mark E. Seamone,Wenjie Wang,Rick Chin,Simon A. Hirota,Yan Li,Sharon A. Clark,Jürg Tschopp,Kiril Trpkov,Brenda R. Hemmelgarn,Paul L. Beck,Daniel A. Muruve +12 more
TL;DR: Results strongly support a role for NLRP3 in renal injury and identify the inflammasome as a possible therapeutic target in the treatment of patients with progressive CKD.
Journal ArticleDOI
Inflammasome-Independent NLRP3 Augments TGF-β Signaling in Kidney Epithelium
Wenjie Wang,Xiangyu Wang,Justin Chun,Akosua Vilaysane,Sharon A. Clark,Gabrielle French,Nathan A. Bracey,Kiril Trpkov,Shirin Bonni,Henry J. Duff,Paul L. Beck,Daniel A. Muruve +11 more
TL;DR: Data support a novel and direct role for NLRP3 in promoting TGF-β signaling and R-Smad activation in epithelial cells independent of the inflammasome.
Journal ArticleDOI
Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo
Daniel A. Muruve,Matthew J. Cotter,Anne K. Zaiss,Lindsay R. White,Qiang Liu,Qiang Liu,Trevor Chan,Sharon A. Clark,P. Joel Ross,Robert A. Meulenbroek,Gunhild Mari Mælandsmo,Robin J. Parks +11 more
TL;DR: HD-Ad vectors induce intact innate but attenuated adaptive immune responses in vivo, and are associated with reduced toxicity and improved safety relative to traditional early region 1 deletion first-generation Ad (FG-Ad) vectors.
Journal ArticleDOI
Complement Is an Essential Component of the Immune Response to Adeno-Associated Virus Vectors
Anne K. Zaiss,Matthew J. Cotter,Lindsay R. White,Sharon A. Clark,Norman C.W. Wong,V. Michael Holers,Jeffrey S. Bartlett,Daniel A. Muruve +7 more
TL;DR: Results show that the complement system is an essential component of the host immune response to AAV, and suggests that the AAV capsid also binds complement regulatory protein factor H.