D
Daniel A. Muruve
Researcher at University of Calgary
Publications - 114
Citations - 12401
Daniel A. Muruve is an academic researcher from University of Calgary. The author has contributed to research in topics: Inflammasome & Innate immune system. The author has an hindex of 47, co-authored 108 publications receiving 10847 citations. Previous affiliations of Daniel A. Muruve include Alberta Health Services & Beth Israel Deaconess Medical Center.
Papers
More filters
Journal ArticleDOI
Intravascular danger signals guide neutrophils to sites of sterile inflammation.
Braedon McDonald,Keir Pittman,Gustavo B. Menezes,Simon A. Hirota,Ingrid Slaba,Christopher C. M. Waterhouse,Paul L. Beck,Daniel A. Muruve,Paul Kubes +8 more
TL;DR: Dynamic in vivo imaging revealed a multistep hierarchy of directional cues that guide neutrophil localization to sites of sterile inflammation, and the underlying mechanisms of recruitment of neutrophils into injured tissue.
Journal ArticleDOI
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
Daniel A. Muruve,Virginie Pétrilli,Anne K. Zaiss,Lindsay R. White,Sharon A. Clark,P. Joel Ross,Robin J. Parks,Jürg Tschopp +7 more
TL;DR: It is shown that internalized adenoviral DNA induces maturation of pro-interleukin-1β in macrophages, which is dependent on NALP3 and ASC, components of the innate cytosolic molecular complex termed the inflammasome, which strengthens their central role in innate immunity.
Journal ArticleDOI
The inflammasome: a danger sensing complex triggering innate immunity.
TL;DR: The important role of the NalP3 inflammasome is emphasized by the identification of mutations in the NALP3 gene that are associated with a susceptibility to inflammatory disorders.
Journal ArticleDOI
Inflammasomes in the CNS
TL;DR: The current understanding of the functions of different inflammasomes in the CNS and their roles in neurological diseases is reviewed.
Journal ArticleDOI
The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD
Akosua Vilaysane,Justin Chun,Mark E. Seamone,Wenjie Wang,Rick Chin,Simon A. Hirota,Yan Li,Sharon A. Clark,Jürg Tschopp,Kiril Trpkov,Brenda R. Hemmelgarn,Paul L. Beck,Daniel A. Muruve +12 more
TL;DR: Results strongly support a role for NLRP3 in renal injury and identify the inflammasome as a possible therapeutic target in the treatment of patients with progressive CKD.