S
Simon A. Hirota
Researcher at University of Calgary
Publications - 83
Citations - 4555
Simon A. Hirota is an academic researcher from University of Calgary. The author has contributed to research in topics: Pregnane X receptor & Colitis. The author has an hindex of 26, co-authored 72 publications receiving 3755 citations. Previous affiliations of Simon A. Hirota include Cardiovascular Institute of the South & St. Joseph Hospital.
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Journal ArticleDOI
Intravascular danger signals guide neutrophils to sites of sterile inflammation.
Braedon McDonald,Keir Pittman,Gustavo B. Menezes,Simon A. Hirota,Ingrid Slaba,Christopher C. M. Waterhouse,Paul L. Beck,Daniel A. Muruve,Paul Kubes +8 more
TL;DR: Dynamic in vivo imaging revealed a multistep hierarchy of directional cues that guide neutrophil localization to sites of sterile inflammation, and the underlying mechanisms of recruitment of neutrophils into injured tissue.
Journal ArticleDOI
The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD
Akosua Vilaysane,Justin Chun,Mark E. Seamone,Wenjie Wang,Rick Chin,Simon A. Hirota,Yan Li,Sharon A. Clark,Jürg Tschopp,Kiril Trpkov,Brenda R. Hemmelgarn,Paul L. Beck,Daniel A. Muruve +12 more
TL;DR: Results strongly support a role for NLRP3 in renal injury and identify the inflammasome as a possible therapeutic target in the treatment of patients with progressive CKD.
Journal ArticleDOI
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
Simon A. Hirota,Jeffrey Ng,Alan Lueng,Maitham A. Khajah,Ken Kuljit S. Parhar,Yan Li,Victor Lam,Mireille S. Potentier,Kelvin Ng,Misha Bawa,Donna-Marie McCafferty,Kevin P. Rioux,Subrata Ghosh,Ramnik J. Xavier,Sean P. Colgan,Jürg Tschopp,Daniel A. Muruve,Justin A. MacDonald,Paul L. Beck +18 more
TL;DR: An essential role for the NLRP3 inflammasome is confirmed in the maintenance of intestinal homeostasis through its regulation of innate protective processes and biological insight into disease mechanisms associated with increased risk of CD in individuals withNLRP3 mutations is provided.
Journal ArticleDOI
Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis.
Brian D. Gulbransen,Mohammad Bashashati,Simon A. Hirota,Xianyong Gui,Jane Roberts,Justin A. MacDonald,Daniel A. Muruve,Derek M. McKay,Paul L. Beck,Gary M. Mawe,Roger J. Thompson,Keith A. Sharkey +11 more
TL;DR: It is reported that inflammation causes enteric neuron death by activating a neuronal signaling complex composed of P2X7 receptors, pannexin-1 channels, the Asc adaptor protein and caspases, and it is concluded that activation of neuronal Panx1 underlies neuron death and the subsequent development of abnormal gut motility in IBD.
Journal ArticleDOI
Clostridium difficile Toxin–Induced Inflammation and Intestinal Injury Are Mediated by the Inflammasome
Jeffrey Ng,Simon A. Hirota,Olaf Gross,Yan Li,Annegret Ulke–Lemee,Mireille S. Potentier,L. Patrick Schenck,Akosua Vilaysane,Mark E. Seamone,Hanping Feng,Glen D. Armstrong,Jürg Tschopp,Justin A. MacDonald,Daniel A. Muruve,Paul L. Beck +14 more
TL;DR: TcdA and TcdB trigger IL-1beta release by activating an ASC-containing inflammasome, a response that contributes to toxin-induced inflammation and damage in vivo.