A
Akosua Vilaysane
Researcher at University of Calgary
Publications - 9
Citations - 1914
Akosua Vilaysane is an academic researcher from University of Calgary. The author has contributed to research in topics: Inflammasome & Innate immune system. The author has an hindex of 9, co-authored 9 publications receiving 1644 citations.
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Journal ArticleDOI
The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD
Akosua Vilaysane,Justin Chun,Mark E. Seamone,Wenjie Wang,Rick Chin,Simon A. Hirota,Yan Li,Sharon A. Clark,Jürg Tschopp,Kiril Trpkov,Brenda R. Hemmelgarn,Paul L. Beck,Daniel A. Muruve +12 more
TL;DR: Results strongly support a role for NLRP3 in renal injury and identify the inflammasome as a possible therapeutic target in the treatment of patients with progressive CKD.
Journal ArticleDOI
Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
Tracy L. Flach,Gilbert Ng,Aswin Hari,Melanie D. Desrosiers,Ping Zhang,Sandra Ward,Mark E. Seamone,Akosua Vilaysane,Ashley D. Mucsi,Yin Fong,Elmar J. Prenner,Chang-Chun Ling,Jürg Tschopp,Daniel A. Muruve,Matthias Amrein,Yan Shi +15 more
TL;DR: This study reports that, independent of inflammasome and membrane proteins, alum binds dendritic cell (DC) plasma membrane lipids with substantial force and proposes that alum triggers DC responses by altering membrane lipid structures.
Journal ArticleDOI
Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion
Shrikant R. Mulay,Onkar P. Kulkarni,Khader Valli Rupanagudi,Adriana Migliorini,Murthy N. Darisipudi,Akosua Vilaysane,Daniel A. Muruve,Yan Shi,Fay Munro,Helen Liapis,Hans-Joachim Anders +10 more
TL;DR: It is demonstrated that CaOx crystals trigger IL-1β-dependent innate immunity via the NLRP3/ASC/caspase-1 axis in intrarenal mononuclear phagocytes and directly damage tubular cells, leading to the release of theNLRP3 agonist ATP.
Journal ArticleDOI
Clostridium difficile Toxin–Induced Inflammation and Intestinal Injury Are Mediated by the Inflammasome
Jeffrey Ng,Simon A. Hirota,Olaf Gross,Yan Li,Annegret Ulke–Lemee,Mireille S. Potentier,L. Patrick Schenck,Akosua Vilaysane,Mark E. Seamone,Hanping Feng,Glen D. Armstrong,Jürg Tschopp,Justin A. MacDonald,Daniel A. Muruve,Paul L. Beck +14 more
TL;DR: TcdA and TcdB trigger IL-1beta release by activating an ASC-containing inflammasome, a response that contributes to toxin-induced inflammation and damage in vivo.
Journal ArticleDOI
Inflammasome-Independent NLRP3 Augments TGF-β Signaling in Kidney Epithelium
Wenjie Wang,Xiangyu Wang,Justin Chun,Akosua Vilaysane,Sharon A. Clark,Gabrielle French,Nathan A. Bracey,Kiril Trpkov,Shirin Bonni,Henry J. Duff,Paul L. Beck,Daniel A. Muruve +11 more
TL;DR: Data support a novel and direct role for NLRP3 in promoting TGF-β signaling and R-Smad activation in epithelial cells independent of the inflammasome.