Y
Yan Li
Researcher at University of Calgary
Publications - 18
Citations - 1438
Yan Li is an academic researcher from University of Calgary. The author has contributed to research in topics: Inflammasome & Clostridium difficile toxin A. The author has an hindex of 10, co-authored 17 publications receiving 1261 citations.
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Journal ArticleDOI
The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD
Akosua Vilaysane,Justin Chun,Mark E. Seamone,Wenjie Wang,Rick Chin,Simon A. Hirota,Yan Li,Sharon A. Clark,Jürg Tschopp,Kiril Trpkov,Brenda R. Hemmelgarn,Paul L. Beck,Daniel A. Muruve +12 more
TL;DR: Results strongly support a role for NLRP3 in renal injury and identify the inflammasome as a possible therapeutic target in the treatment of patients with progressive CKD.
Journal ArticleDOI
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
Simon A. Hirota,Jeffrey Ng,Alan Lueng,Maitham A. Khajah,Ken Kuljit S. Parhar,Yan Li,Victor Lam,Mireille S. Potentier,Kelvin Ng,Misha Bawa,Donna-Marie McCafferty,Kevin P. Rioux,Subrata Ghosh,Ramnik J. Xavier,Sean P. Colgan,Jürg Tschopp,Daniel A. Muruve,Justin A. MacDonald,Paul L. Beck +18 more
TL;DR: An essential role for the NLRP3 inflammasome is confirmed in the maintenance of intestinal homeostasis through its regulation of innate protective processes and biological insight into disease mechanisms associated with increased risk of CD in individuals withNLRP3 mutations is provided.
Journal ArticleDOI
Clostridium difficile Toxin–Induced Inflammation and Intestinal Injury Are Mediated by the Inflammasome
Jeffrey Ng,Simon A. Hirota,Olaf Gross,Yan Li,Annegret Ulke–Lemee,Mireille S. Potentier,L. Patrick Schenck,Akosua Vilaysane,Mark E. Seamone,Hanping Feng,Glen D. Armstrong,Jürg Tschopp,Justin A. MacDonald,Daniel A. Muruve,Paul L. Beck +14 more
TL;DR: TcdA and TcdB trigger IL-1beta release by activating an ASC-containing inflammasome, a response that contributes to toxin-induced inflammation and damage in vivo.
Journal ArticleDOI
Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor.
Paul L. Beck,Josee Wong,Yan Li,Sunita Swaminathan,Ramnik J. Xavier,Kathryn L. Devaney,Daniel K. Podolsky +6 more
TL;DR: Oral recombinant intestinal trefoil factor reduced the severity of both chemotherapy-induced and chemotherapy/radiotherapy-induced intestinal mucositis and improved intestinal epithelial cell viability and wound repair after chemotherapy exposure in vitro.
Journal ArticleDOI
Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury
Simon A. Hirota,Kyla Fines,Jeffrey Ng,Danya Traboulsi,Josh Lee,Eikichi Ihara,Yan Li,William G. Willmore,Daniel C. Chung,Melanie Scully,Thomas J. Louie,Shaun A.C. Medlicott,Manigandan Lejeune,Kris Chadee,Glen D. Armstrong,Sean P. Colgan,Daniel A. Muruve,Justin A. MacDonald,Paul L. Beck +18 more
TL;DR: It is proposed that hypoxia-inducible factor (HIF-1) has an innate, protective role in C difficile colitis and should be developed as therapeutics for C Difficile-associated disease.