S
Sharon Mudie
Researcher at University of Dundee
Publications - 15
Citations - 837
Sharon Mudie is an academic researcher from University of Dundee. The author has contributed to research in topics: Transcription factor & IκB kinase. The author has an hindex of 13, co-authored 15 publications receiving 709 citations.
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Journal ArticleDOI
Mechanism of Hypoxia-Induced NF-κB
Carolyn Culver,Anders Sundqvist,Sharon Mudie,Andrew Melvin,Dimitris P. Xirodimas,Sonia Rocha +5 more
TL;DR: In this article, a calcium/calmodulin-dependent kinase 2 (CaMK2)-dependent pathway was proposed to activate NF-κB in response to hypoxia.
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Evolutionary conserved regulation of HIF-1β by NF-κB
TL;DR: A novel mechanism of HIF regulation is revealed, with impact in the development of novel therapeutic strategies for HIF–related pathologies including ageing, ischemia, and cancer.
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SWI/SNF regulates the cellular response to hypoxia.
TL;DR: The results reveal a previously uncharacterized dependence of hypoxia signaling on the SWI/SNF complex and demonstrate a new level of control over the Hypoxia-inducible factor-1α system.
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HIF-1α restricts NF-κB dependent gene expression to control innate immunity signals
TL;DR: It is shown that HIF-1α represses NF-κB-dependent gene expression and prevents excessive and damaging pro-inflammatory responses in mammalian cells and in the model organism Drosophila melanogaster.
Journal ArticleDOI
PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192
Sandra C. Moser,Dalila Bensaddek,Brian Ortmann,Jean-François Maure,Sharon Mudie,J. Julian Blow,Angus I. Lamond,Jason R. Swedlow,Sonia Rocha +8 more
TL;DR: By modulating Cep192 levels, PHD1 thereby affects the processes of centriole duplication and centrosome maturation and contributes to the regulation of cell-cycle progression.