S
Sharon R. Grossman
Researcher at Broad Institute
Publications - 25
Citations - 10540
Sharon R. Grossman is an academic researcher from Broad Institute. The author has contributed to research in topics: Enhancer & Gene. The author has an hindex of 18, co-authored 21 publications receiving 8613 citations. Previous affiliations of Sharon R. Grossman include Harvard University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Positional specificity of different transcription factor classes within enhancers
Sharon R. Grossman,Sharon R. Grossman,Sharon R. Grossman,Jesse M. Engreitz,John P. Ray,Tung T. Nguyen,Nir Hacohen,Nir Hacohen,Eric S. Lander,Eric S. Lander,Eric S. Lander +10 more
TL;DR: It is shown that the positional distribution of TF motif sites within nucleosome-depleted regions of DNA fall into six distinct classes, suggesting that distinct classes of TFs display different binding preferences, which may reflect TF-specific intrinsic structural or functional characteristics.
Journal ArticleDOI
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk.
Yakir A. Reshef,Yakir A. Reshef,Yakir A. Reshef,Hilary K. Finucane,David R. Kelley,Alexander Gusev,Dylan Kotliar,Jacob C. Ulirsch,Jacob C. Ulirsch,Jacob C. Ulirsch,Farhad Hormozdiari,Farhad Hormozdiari,Joseph Nasser,Luke J. O’Connor,Bryce van de Geijn,Po-Ru Loh,Po-Ru Loh,Sharon R. Grossman,Sharon R. Grossman,Gaurav Bhatia,Steven Gazal,Pier Francesco Palamara,Pier Francesco Palamara,Pier Francesco Palamara,Luca Pinello,Luca Pinello,Nick Patterson,Ryan P. Adams,Ryan P. Adams,Alkes L. Price,Alkes L. Price +30 more
TL;DR: Signed linkage disequilibrium profile regression is a new method for detecting directional effects of genomic annotations on disease risk that implicate new causal disease genes and can suggest mechanisms underlying the effects of causal genes on disease.
Journal ArticleDOI
Compatibility rules of human enhancer and promoter sequences
Drew T. Bergman,Thouis R. Jones,Vincent Liu,Judhajeet Ray,Evelyn Jagoda,Layla Siraj,Helen Y. Kang,Joseph Nasser,Michael Kane,Antonio Ray Rios,Sharon R. Grossman,Charles P. Fulco,Eric S. Lander,Jesse M. Engreitz +13 more
TL;DR: In this paper , the authors identify simple rules for enhancer-promoter compatibility, whereby most enhancers activate all promoters by similar amounts, and intrinsic enhancer and promoter activities multiplicatively combine to determine RNA output (R2 = 0.82).
Journal ArticleDOI
Compatibility rules of human enhancer and promoter sequences
Drew T. Bergman,Thouis R. Jones,Vincent Liu,Judhajeet Ray,Evelyn Jagoda,Layla Siraj,Helen Y. Kang,Joseph Nasser,Michael Kane,Antonio Ray Rios,Sharon R. Grossman,Charles P. Fulco,Eric S. Lander,Jesse M. Engreitz +13 more
TL;DR: In this paper , the authors identify simple rules for enhancer-promoter compatibility, whereby most enhancers activate all promoters by similar amounts, and intrinsic enhancer and promoter activities multiplicatively combine to determine RNA output (R2 = 0.82).
Journal ArticleDOI
Ancient and Recent Adaptive Evolution of Primate Non-Homologous End Joining Genes
Ann Demogines,Alysia M. East,Ji-Hoon Lee,Ji-Hoon Lee,Sharon R. Grossman,Pardis C. Sabeti,Tanya T. Paull,Sara L. Sawyer +7 more
TL;DR: It is proposed that an ongoing evolutionary arms race between viruses and NHEJ genes may be driving the surprisingly rapid evolution of these critical genes.