S
Sharon R. Grossman
Researcher at Broad Institute
Publications - 25
Citations - 10540
Sharon R. Grossman is an academic researcher from Broad Institute. The author has contributed to research in topics: Enhancer & Gene. The author has an hindex of 18, co-authored 21 publications receiving 8613 citations. Previous affiliations of Sharon R. Grossman include Harvard University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Activity-by-contact model of enhancer-promoter regulation from thousands of CRISPR perturbations.
Charles P. Fulco,Charles P. Fulco,Joseph Nasser,Thouis R. Jones,Glen Munson,Drew T. Bergman,Vidya Subramanian,Sharon R. Grossman,Sharon R. Grossman,Rockwell Anyoha,Benjamin R. Doughty,Tejal A. Patwardhan,Tung T. Nguyen,Michael Kane,Elizabeth M. Perez,Neva C. Durand,Caleb A. Lareau,Elena K. Stamenova,Erez Lieberman Aiden,Eric S. Lander,Eric S. Lander,Eric S. Lander,Jesse M. Engreitz,Jesse M. Engreitz +23 more
TL;DR: A simple activity-by-contact model substantially outperformed previous methods at predicting the complex connections in the CRISPR dataset and allows systematic mapping of enhancer–gene connections in a given cell type, on the basis of chromatin-state measurements.
Journal ArticleDOI
Systematic mapping of functional enhancer-promoter connections with CRISPR interference
Charles P. Fulco,Charles P. Fulco,Mathias Munschauer,Rockwell Anyoha,Glen Munson,Sharon R. Grossman,Sharon R. Grossman,Elizabeth M. Perez,Michael Kane,Brian Cleary,Brian Cleary,Eric S. Lander,Eric S. Lander,Eric S. Lander,Jesse M. Engreitz +14 more
TL;DR: A high-throughput approach that uses clustered regularly interspaced short palindromic repeats (CRISPRi) interference to discover regulatory elements and identify their target genes and can be applied to dissect transcriptional networks and interpret the contributions of noncoding genetic variation to human disease.
Journal ArticleDOI
A Composite of Multiple Signals Distinguishes Causal Variants in Regions of Positive Selection
Sharon R. Grossman,Sharon R. Grossman,Ilya Shylakhter,Ilya Shylakhter,Elinor K. Karlsson,Elinor K. Karlsson,Elizabeth H. Byrne,Elizabeth H. Byrne,Shannon Morales,Shannon Morales,Shannon Morales,Gabriel Frieden,Elizabeth Hostetter,Elizabeth Hostetter,Elaine Angelino,Manuel Garber,Or Zuk,Eric S. Lander,Eric S. Lander,Eric S. Lander,Stephen F. Schaffner,Pardis C. Sabeti,Pardis C. Sabeti +22 more
TL;DR: A method, composite of multiple signals (CMS), that combines tests for multiple signals of selection and increases resolution by up to 100-fold is developed, which can increase the ability to pinpoint the specific variant under selection.
Journal ArticleDOI
RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites.
Jesse M. Engreitz,Jesse M. Engreitz,Klara Sirokman,Patrick McDonel,Alexander A. Shishkin,Christine Surka,Pamela Russell,Sharon R. Grossman,Sharon R. Grossman,Amy Y. M. Chow,Mitchell Guttman,Eric S. Lander,Eric S. Lander,Eric S. Lander +13 more
TL;DR: In this article, a method based on RNA antisense purification was developed to systematically map RNA-RNA interactions (RAP-RNA) and applied it to investigate two ncRNAs implicated in RNA processing.
RNA-RNA Interactions Enable Specific Targeting of Noncoding RNAs to Nascent Pre-mRNAs and Chromatin Sites
Klara Sirokman,Patrick McDonel,Alexander A. Shishkin,Christine Surka,Pamela Russell,Amy Y. M. Chow,Mitchell Guttman,Eric S. Lander,Jesse M. Engreitz,Sharon R. Grossman +9 more
TL;DR: Interactions with nascent pre-mRNAs cause U1 and Malat1 to localize proximally to chromatin at active genes, demonstrating that ncRNAs can use RNA-RNA interactions to target specific pre- mRNAs and genomic sites.