S
Sharon R. Grossman
Researcher at Broad Institute
Publications - 25
Citations - 10540
Sharon R. Grossman is an academic researcher from Broad Institute. The author has contributed to research in topics: Enhancer & Gene. The author has an hindex of 18, co-authored 21 publications receiving 8613 citations. Previous affiliations of Sharon R. Grossman include Harvard University & Massachusetts Institute of Technology.
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Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk
Yakir A. Reshef,Hilary K. Finucane,David R. Kelley,Alexander Gusev,Dylan Kotliar,Jacob C. Ulirsch,Farhad Hormozdiari,Joseph Nasser,Luke J. O’Connor,Bryce van de Geijn,Po-Ru Loh,Sharon R. Grossman,Gaurav Bhatia,Steven Gazal,Pier Francesco Palamara,Luca Pinello,Nick Patterson,Ryan P. Adams,Alkes L. Price +18 more
TL;DR: A new method is introduced, signed LD profile regression, for detecting directional effects of GWAS summary statistics on disease risk enable stronger statements about causal mechanisms of disease than enrichments of corresponding unsigned annotations.
Posted ContentDOI
Activity-by-Contact model of enhancer specificity from thousands of CRISPR perturbations
Charles P. Fulco,Charles P. Fulco,Joseph Nasser,Thouis R. Jones,Glen Munson,Drew T. Bergman,Vidya Subramanian,Sharon R. Grossman,Rockwell Anyoha,Tejal A. Patwardhan,Tung T. Nguyen,Michael Kane,Benjamin R. Doughty,Elizabeth M. Perez,Neva C. Durand,Elena K. Stamenova,Erez Lieberman Aiden,Eric S. Lander,Eric S. Lander,Jesse M. Engreitz,Jesse M. Engreitz +20 more
TL;DR: Together, CRISPRi-FlowFISH and the ABC model provide a systematic approach to map and predict which enhancers regulate which genes, and will help to interpret the functions of the thousands of disease risk variants in the noncoding genome.
Journal ArticleDOI
Inferring gene regulation from stochastic transcriptional variation across single cells at steady state
Anika Gupta,Jorge Diego Martin-Rufino,Thouis R. Jones,Vidya Subramanian,Xiaojie Qiu,Emmanuelle I Grody,Alexander Bloemendal,Chen-yin Weng,Sheng-Yong Niu,Kyung Hoi Min,Arnav Mehta,Kaite Zhang,Layla Siraj,Aziz Al' Khafaji,Vijay G. Sankaran,Soumya Raychaudhuri,Brian Cleary,Sharon R. Grossman,Eric S. Lander +18 more
TL;DR: It is shown that, with enough data, it should be possible to identify regulatory relationships within a cell type without need for perturbation, by leveraging the intrinsic stochasticity in transcriptional bursting across individual cells at steady-state.
Posted ContentDOI
Compatibility logic of human enhancer and promoter sequences
Drew T. Bergman,Drew T. Bergman,Thouis R. Jones,Vincent Liu,Layla Siraj,Layla Siraj,Helen Y. Kang,Joseph Nasser,Michael Kane,Tung T. Nguyen,Sharon R. Grossman,Charles P. Fulco,Charles P. Fulco,Eric S. Lander,Jesse M. Engreitz,Jesse M. Engreitz +15 more
TL;DR: In this article, the authors designed a high-throughput reporter assay called enhancer x promoter (ExP) STARR-seq and applied it to examine the combinatorial compatibilities of 1,000 enhancer and 1, 000 promoter sequences in human K562 cells.
Posted ContentDOI
Genetic Evidence Causally Linking Pancreas Fat to Pancreatic Cancer: A Mendelian Randomization Study
Hideko Yamazaki,Samantha A. Streicher,Shota Fukuhara,Robert Wagner,Martin Heni,Sharon R. Grossman,H. J. Lenz,Veronica Wendy Setiawan,Loic Le Marchand,Barry Huang +9 more
TL;DR: In this paper , the authors investigated whether pancreas fat is causally associated with PDAC using two-sample Mendelian randomization, and provided genetic evidence for a causal role of pancreatas fat in the pathogenesis of PDAC.