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Shawn Kalloway
Researcher at Medical College of Wisconsin
Publications - 7
Citations - 1362
Shawn Kalloway is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Placenta & Thrombomodulin. The author has an hindex of 5, co-authored 7 publications receiving 1299 citations. Previous affiliations of Shawn Kalloway include Gulf Coast Regional Blood Center & Sangamo BioSciences.
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Journal ArticleDOI
Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases
Aron M. Geurts,Gregory J. Cost,Yevgeniy Freyvert,Bryan Zeitler,Jeffrey C. Miller,Vivian M. Choi,Shirin S Jenkins,Adam Wood,Xiaoxia Cui,Xiangdong Meng,Anna I Vincent,Stephen Lam,Mieczyslaw Michalkiewicz,Rebecca Schilling,Jamie Foeckler,Shawn Kalloway,Hartmut Weiler,Séverine Ménoret,Ignacio Anegon,Gregory D. Davis,Lei Zhang,Edward J. Rebar,Philip D. Gregory,Fyodor D. Urnov,Howard J. Jacob,Roland Buelow +25 more
TL;DR: It is demonstrated that a single injection of DNA or messenger RNA encoding ZFNs into the one-cell rat embryo leads to a high frequency of animals carrying 25 to 100% disruption at the target locus.
Journal ArticleDOI
The thrombomodulin-protein C system is essential for the maintenance of pregnancy.
Berend Isermann,Rashmi Sood,Rafal Pawlinski,Mark Zogg,Shawn Kalloway,Jay L. Degen,Nigel Mackman,Hartmut Weiler,Hartmut Weiler +8 more
TL;DR: Findings show a new function for the thrombomodulin–protein C system in controlling the growth and survival of trophoblast cells in the placenta, essential for the maintenance of pregnancy.
Journal ArticleDOI
Fetomaternal cross talk in the placental vascular bed: control of coagulation by trophoblast cells
Rashmi Sood,Shawn Kalloway,Shawn Kalloway,Alan E. Mast,Alan E. Mast,Cecilia J. Hillard,Cecilia J. Hillard,Hartmut Weiler,Hartmut Weiler +8 more
TL;DR: The observations define candidate fetal genes that are potential risk modifiers of maternal thrombophilia-associated pregnancy complications and provide evidence that coagulation activation at the fetomaternal interface can affect trophoblast physiology altering placental function in the absence of frankThrombosis.
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Variable phenotypic penetrance of thrombosis in adult mice after tissue-selective and temporally controlled Thbd gene inactivation
Thijs E. van Mens,Hai-Po H. Liang,Sreemanti Basu,Irene Hernandez,Mark Zogg,Jennifer May,Min Zhan,Qiuhui Yang,Jamie Foeckler,Shawn Kalloway,Rashmi Sood,Caren Sue Karlson,Hartmut Weiler,Hartmut Weiler +13 more
TL;DR: Findings suggest that Thbd function in nonendothelial embryonic tissues of the placenta and yolk sac affects through as-yet-unknown mechanisms the penetrance and severity of thrombosis after birth and provide novel opportunities to study the role of the natural Thbd-pC pathway in adult mice and during pregnancy.
Journal ArticleDOI
Defective collagen binding and increased bleeding in a murine model of von Willebrand disease affecting collagen IV binding.
Tricia L Slobodianuk,Tricia L Slobodianuk,Caroline E Kochelek,Caroline E Kochelek,Jamie Foeckler,Shawn Kalloway,Hartmut Weiler,Veronica H. Flood,Veronica H. Flood,Veronica H. Flood +9 more
TL;DR: A murine model of defective VWF‐collagen IV interactions with VWF variant p.R1399H homozygous mice had decreased binding to collagen IV and increased bleeding times.