S
Sheila J. Jones
Researcher at University College London
Publications - 130
Citations - 7494
Sheila J. Jones is an academic researcher from University College London. The author has contributed to research in topics: Resorption & Bone cell. The author has an hindex of 45, co-authored 130 publications receiving 7309 citations. Previous affiliations of Sheila J. Jones include University of Cambridge & University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice
Paul Saftig,Ernst Hunziker,Olaf Wehmeyer,Sheila J. Jones,Alan Boyde,Winfried Rommerskirch,Jörg Detlev Moritz,Peter Schu,Kurt von Figura +8 more
TL;DR: Assaying the resorptive activity of cathepsin-K-deficient osteoclasts in vitro revealed this function to be severely impaired, which supports the contention that cathepsypsin K is of major importance in bone remodeling.
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Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures.
Naoyuki Takahashi,Hiromi Yamana,Shusaku Yoshiki,G D Roodman,G R Mundy,G R Mundy,Sheila J. Jones,Sheila J. Jones,Alan Boyde,Tatsuo Suda +9 more
TL;DR: TRACP-positive multinucleated cells formed in response to osteotropic hormones in mouse marrow cultures satisfy most of the criteria of osteoclasts, and osteoblasts may play an important role in osteoclast formation.
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Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis
Alison R. Hayman,Sheila J. Jones,Alan Boyde,Diane Foster,William H. Colledge,Mark B. L. Carlton,Martin J. Evans,Timothy M. Cox +7 more
TL;DR: It is concluded that this bifunctional metalloprotein of the osteoclast is required for normal mineralization of cartilage in developing bones; it also maintains integrity and turnover of the adult skeleton by a critical contribution to bone matrix resorption.
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Resorption of dentine by isolated osteoclasts in vitro
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The speed of post mortem change to the human skeleton and its taphonomic significance
TL;DR: The results from this study have significantly brought forward the time of known onset for post mortem alteration for 3 morphological types of microstructural change, the earliest of which was 3 months post Mortem.