S
Sheila K. Singh
Researcher at McMaster University
Publications - 180
Citations - 17443
Sheila K. Singh is an academic researcher from McMaster University. The author has contributed to research in topics: Stem cell & Population. The author has an hindex of 33, co-authored 141 publications receiving 15654 citations. Previous affiliations of Sheila K. Singh include Hamilton Health Sciences & McMaster Children's Hospital.
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Journal ArticleDOI
Identification of human brain tumour initiating cells
Sheila K. Singh,Cynthia Hawkins,Ian D. Clarke,Jeremy A. Squire,Jane Bayani,Takuichiro Hide,R. Mark Henkelman,Michael D. Cusimano,Peter B. Dirks +8 more
TL;DR: The development of a xenograft assay that identified human brain tumour initiating cells that initiate tumours in vivo gives strong support for the CSC hypothesis as the basis for many solid tumours, and establishes a previously unidentified cellular target for more effective cancer therapies.
Journal Article
Identification of a Cancer Stem Cell in Human Brain Tumors
Sheila K. Singh,Ian D. Clarke,Mizuhiko Terasaki,Victoria E. Bonn,Cynthia Hawkins,Jeremy A. Squire,Peter B. Dirks +6 more
TL;DR: The identification and purification of a cancer stem cell from human brain tumors of different phenotypes that possesses a marked capacity for proliferation, self-renewal, and differentiation is reported.
Journal ArticleDOI
Cancer stem cells in nervous system tumors.
TL;DR: The identification of a brain tumor stem cells (BTSC) provides a powerful tool to investigate the tumorigenic process in the central nervous system and to develop therapies targeted to the BTSC.
Journal ArticleDOI
Endovascular Thrombectomy for Acute Ischemic Stroke: A Meta-analysis
Jetan H. Badhiwala,Farshad Nassiri,Waleed Alhazzani,Magdy Selim,Forough Farrokhyar,Julian Spears,Abhaya V. Kulkarni,Sheila K. Singh,Abdulrahman Alqahtani,Bram Rochwerg,Mohammad S Al-Shahrani,Naresh Murty,Adel Alhazzani,Blake Yarascavitch,Kesava Reddy,Osama O. Zaidat,Saleh A. Almenawer +16 more
TL;DR: Among patients with acute ischemic stroke, endovascular therapy with mechanical thrombectomy vs standard medical care with tPA was associated with improved functional outcomes and higher rates of angiographic revascularization, but no significant difference in symptomatic intracranial hemorrhage or all-cause mortality at 90 days.
Journal ArticleDOI
Chronic subdural hematoma management: a systematic review and meta-analysis of 34,829 patients.
Saleh A. Almenawer,Forough Farrokhyar,Chris J. Hong,Waleed Alhazzani,Branavan Manoranjan,Blake Yarascavitch,Parnian Arjmand,Benedicto Baronia,Kesava Reddy,Naresh Murty,Sheila K. Singh +10 more
TL;DR: Percutaneous bedside twist-drill drainage is a relatively safe and effective first-line management option for chronic subdural hematoma patients with CSDH and may result in potential health cost savings and eliminate perioperative risks related to general anesthetic.