J
Jane Bayani
Researcher at Ontario Institute for Cancer Research
Publications - 96
Citations - 11254
Jane Bayani is an academic researcher from Ontario Institute for Cancer Research. The author has contributed to research in topics: Comparative genomic hybridization & Cancer. The author has an hindex of 36, co-authored 82 publications receiving 10399 citations. Previous affiliations of Jane Bayani include University of Toronto & Mount Sinai Hospital, Toronto.
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Journal ArticleDOI
Identification of human brain tumour initiating cells
Sheila K. Singh,Cynthia Hawkins,Ian D. Clarke,Jeremy A. Squire,Jane Bayani,Takuichiro Hide,R. Mark Henkelman,Michael D. Cusimano,Peter B. Dirks +8 more
TL;DR: The development of a xenograft assay that identified human brain tumour initiating cells that initiate tumours in vivo gives strong support for the CSC hypothesis as the basis for many solid tumours, and establishes a previously unidentified cellular target for more effective cancer therapies.
Journal ArticleDOI
Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.
Mona Meyer,Jüri Reimand,Xiaoyang Lan,Renee Head,Xueming Zhu,Michelle Kushida,Jane Bayani,Jessica C. Pressey,Anath C. Lionel,Ian D. Clarke,Michael D. Cusimano,Jeremy A. Squire,Stephen W. Scherer,Mark Bernstein,Melanie A. Woodin,Gary D. Bader,Peter B. Dirks +16 more
TL;DR: It is predicted that integration of functional and genomic analysis at a clonal level will be essential for understanding evolution and therapeutic resistance of human cancer, and will lead to the discovery of novel driver mechanisms and clone-specific cancer treatment.
Journal ArticleDOI
Characterization of male breast cancer: Results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program
Fatima Cardoso,Fatima Cardoso,John M. S. Bartlett,John M. S. Bartlett,Leen Slaets,C.H.M. van Deurzen,C.H.M. van Deurzen,E van Leeuwen-Stok,Peggy L. Porter,Peggy L. Porter,B. Linderholm,B. Linderholm,Ingrid Hedenfalk,Carolien P. Schröder,Carolien P. Schröder,John W.M. Martens,John W.M. Martens,Jane Bayani,C. J. van Asperen,C. J. van Asperen,Melissa Murray,Clifford A. Hudis,Clifford A. Hudis,Lavinia P. Middleton,Joanna Vermeij,Kevin Punie,Judith Fraser,M Nowaczyk,Isabel T. Rubio,Stefan Aebi,Catherine M. Kelly,Kathryn J. Ruddy,Eric P. Winer,Cecilia Nilsson,L. Dal Lago,Larissa A. Korde,Kim Benstead,Oliver Bogler,Theodora Goulioti,Aleksandra Peric,Saskia Litière,K Aalders,C. Poncet,Konstantinos Tryfonidis,Sharon H. Giordano +44 more
TL;DR: Better overall (OS) and recurrence-free survival (RFS) and a significant improvement over time was observed in age-corrected BC mortality and there was no association between OS/RFS and HER-2 status, Ki67, IHC subtypes nor grade.
Journal ArticleDOI
Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement.
Maisa Yoshimoto,Anthony M. Joshua,Anthony M. Joshua,Susan Chilton-MacNeill,Jane Bayani,Shamini Selvarajah,Shamini Selvarajah,Andrew Evans,Maria Zielenska,Jeremy A. Squire +9 more
TL;DR: Three-color fluorescence in situ hybridization confirms that TMPRSS2/ERG fusion may be accompanied by a small hemizygous sequence deletion on chromosome 21 between ERG and TMPR SS2 genes.
Journal ArticleDOI
Single cell derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.
Peter B. Dirks,Mona Meyer,Jüri Reimand,Xiaoyang Lan,Renee Head,Xueming Zhu,Michelle Kushida,Jane Bayani,Jessica C. Pressey,Anath C. Lionel,Ian D. Clarke,Michael D. Cusimano,Jeremy A. Squire,Stephen W. Scherer,Mark Bernstein,Melanie A. Woodin,Gary D. Bader +16 more
TL;DR: The results suggest that functional clonal profiling used to identify tumorigenic and drug resistant tumor clones will lead to the discovery of new GBM clone-specific treatment strategies.