Sheng Da Hsu

TL;DR: Improvements make the miRTarBase one of the more comprehensively annotated, experimentally validated miRNA-target interactions databases and motivate additional miRNA research efforts.

TL;DR: The miRTarBase contains the largest amount of validated MTIs by comparing with other similar, previously developed databases and can also provide a large amount of positive samples to develop computational methods capable of identifying miRNA–target interactions.

TL;DR: The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions, with a 14-fold increase to mi RNA-target interaction entries and recent improvements.

TL;DR: It is demonstrated that mice with a targeted deletion of the Mir122a gene possess several key phenotypes of human liver diseases, which provides a rationale for the development of a unique therapy for the treatment of chronic liver disease and HCC.

TL;DR: The CircNet database is to the authors' knowledge the first public database that provides tissue-specific circRNA expression profiles and circRNA–miRNA-gene regulatory networks and generates an integrated regulatory network that illustrates the regulation between circRNAs, miRNAs and genes.