S
Sheng-Lin Qiao
Researcher at Chinese Academy of Sciences
Publications - 33
Citations - 1353
Sheng-Lin Qiao is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Polymer & Cancer immunotherapy. The author has an hindex of 16, co-authored 31 publications receiving 1026 citations. Previous affiliations of Sheng-Lin Qiao include Center for Excellence in Education.
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Journal ArticleDOI
In Situ Formation of Nanofibers from Purpurin18‐Peptide Conjugates and the Assembly Induced Retention Effect in Tumor Sites
TL;DR: A responsive small-molecule precursor is prepared that simultaneously self-assembles into nanofibers in tumor sites that exhibit an assembly-induced retention effect, which results in an improved PA imaging signal and enhanced therapeutic efficacy.
Journal ArticleDOI
Polymeric nanoparticles promote macrophage reversal from M2 to M1 phenotypes in the tumor microenvironment.
Yi Wang,Yi Wang,Yao-Xin Lin,Yao-Xin Lin,Sheng-Lin Qiao,Sheng-Lin Qiao,Hong-Wei An,Hong-Wei An,Yang Ma,Yang Ma,Zeng-Ying Qiao,R. P. Yeshan J. Rajapaksha,R. P. Yeshan J. Rajapaksha,Hao Wang,Hao Wang +14 more
TL;DR: The strategy was to design a microenvironment-responsive material for local macrophage modification to overcome the physiological barrier of solid tumors and achieve immunomodulation in the microenvironment for cancer therapy, with negligible cytotoxicity.
Journal ArticleDOI
Self‐Assembled Autophagy‐Inducing Polymeric Nanoparticles for Breast Cancer Interference In‐Vivo
Yi Wang,Yao-Xin Lin,Zeng-Ying Qiao,Hong-Wei An,Sheng-Lin Qiao,Lei Wang,R. P. Yeshan J. Rajapaksha,Hao Wang +7 more
TL;DR: The polymer-beclin-1 (P-Bec1) nanoparticles display enhanced cytotoxicity to breast cancer cells through induction of autophagy, and overcomes two major limitations of the haploinsufficient tumor suppressor Bec1 compared to small-molecule drugs.
Journal ArticleDOI
Intracellular construction of topology-controlled polypeptide nanostructures with diverse biological functions
Li-Li Li,Sheng-Lin Qiao,Sheng-Lin Qiao,Wei-Jiao Liu,Wei-Jiao Liu,Yang Ma,Yang Ma,Dong Wan,Jie Pan,Hao Wang,Hao Wang +10 more
TL;DR: An intracellular enzyme-catalyzed polymerization approach for efficient synthesis of polypeptides and in situ construction of topology-controlled nanostructures is reported and it is revealed that the phase behavior and topological structure of polyPEptides are encoded in monomeric peptide sequences.
Journal ArticleDOI
An in Situ Intracellular Self-Assembly Strategy for Quantitatively and Temporally Monitoring Autophagy.
Yao-Xin Lin,Yao-Xin Lin,Sheng-Lin Qiao,Sheng-Lin Qiao,Yi Wang,Yi Wang,Ruo-Xin Zhang,Hong-Wei An,Hong-Wei An,Yang Ma,Yang Ma,R. P. Yeshan J. Rajapaksha,Zeng-Ying Qiao,Lei Wang,Hao Wang,Hao Wang +15 more
TL;DR: This in situ intracellular self-assembly strategy provides a rapid, effective, real-time, and quantitative method for monitoring autophagy in living objects, and it will be a useful tool for autophagic-related fundamental and clinical research.