Shenshen Cai

TL;DR: Highly stable, polymer micelle assemblies known as filomicelles are used to compare the transport and trafficking of flexible filaments with spheres of similar chemistry and show that long-circulating vehicles need not be nanospheres.

TL;DR: Comparisons of polymersomes with viral capsids are shown to encompass and inspire many aspects of current designs, and polymersome loading, in vivo stealthiness, degradation-based disassembly for controlled release, and even tumor-shrinkage in vivo are reviewed.

TL;DR: Robustness together with recently described mechanisms for controlled breakdown of degradable polymersomes as well as escape from endolysosomes suggests that polymersome might be usefully viewed as having structure/property/function relationships somewhere between lipid vesicles and viral capsids.

TL;DR: PEO–PCL based worm-like filomicelles appear to be promising pharmaceutical nanocarriers with improved solubilization efficiency and comparable stability to spherical micelles, as well as better safety and efficacy in vitro compared to the prevalent Cremophor® EL TAX formulation.

TL;DR: In tumor-bearing mice, the higher dose of tax produces greater and more sustained tumor shrinkage and tumor cell apoptosis, and the results thus begin to address mechanisms for how nonspherical carriers deliver both imaging agents and anticancer therapeutics to solid tumors.