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Ichiro Sakata
Researcher at Saitama University
Publications - 103
Citations - 4791
Ichiro Sakata is an academic researcher from Saitama University. The author has contributed to research in topics: Ghrelin & Motilin. The author has an hindex of 33, co-authored 97 publications receiving 4353 citations. Previous affiliations of Ichiro Sakata include University of Texas Southwestern Medical Center & University of Tsukuba.
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Journal ArticleDOI
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress
Michael Lutter,Ichiro Sakata,Sherri Osborne-Lawrence,Sherry A. Rovinsky,Jason G. Anderson,Saendy Jung,Shari G. Birnbaum,Masashi Yanagisawa,Joel K. Elmquist,Eric J. Nestler,Jeffrey M. Zigman +10 more
TL;DR: It is found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test, demonstrating a previously unknown function for ghrel in defending against depressive-like symptoms of chronic stress.
Journal ArticleDOI
Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner.
Mario Perello,Ichiro Sakata,Shari G. Birnbaum,Jen Chieh Chuang,Sherri Osborne-Lawrence,Sherry A. Rovinsky,Jakub Woloszyn,Masashi Yanagisawa,Michael Lutter,Jeffrey M. Zigman +9 more
TL;DR: The results demonstrate an obligatory role for ghrelin in certain rewarding aspects of eating that is separate from eating associated with body weight homeostasis and that requires the presence of intact orexin signaling.
Journal ArticleDOI
Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract.
Ichiro Sakata,Kazuaki Nakamura,Mami Yamazaki,Maki Matsubara,Yuijiro Hayashi,Kenji Kangawa,Takafumi Sakai +6 more
TL;DR: The results suggest that the two types of ghrelin cells may be distinctly regulated and play different physiological roles in various regions of the gastrointestinal tract.
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A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin
Kristoffer L. Egerod,Maja S. Engelstoft,Kaare V. Grunddal,Mark K. Nøhr,Anna Secher,Ichiro Sakata,Jens Pedersen,Johanne Agerlin Windeløv,Ernst-Martin Füchtbauer,Jørgen Olsen,Frank Sundler,Jan Pravsgaard Christensen,Nils Wierup,Jesper V. Olsen,Jens J. Holst,Jeffrey M. Zigman,Steen Seier Poulsen,Thue W. Schwartz +17 more
TL;DR: It is concluded that a lineage of mature enteroendocrine cells have the ability to coexpress members of a group of functionally related peptides: CCK, secretin, GIP, GLP-1, PYY, and neurotensin, suggesting a potential therapeutic target for the treatment and prevention of diabetes and obesity.
Journal ArticleDOI
Ghrelin mediates stress-induced food-reward behavior in mice
Jen Chieh Chuang,Mario Perello,Ichiro Sakata,Sherri Osborne-Lawrence,Joseph M. Savitt,Michael Lutter,Jeffrey M. Zigman +6 more
TL;DR: This mouse model has allowed us to ascribe a role for ghrelin-engaged catecholaminergic neurons in stress-induced eating, and to describe a system in which food-reward behavior is monitored in mice after exposure to chronic social defeat stress.