Shi Chung Ng

TL;DR: Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation.

TL;DR: A series of indole containing oxazolines has been discovered as a result of structural modifications of the lead compound A-105972, and A-289099 was identified as an orally active antimitotic agent active against various cancer cell lines including those that express the MDR phenotype.

TL;DR: Sulfonate analogues of combretastatin A-4 have been prepared as mentioned in this paper, which are potent inhibitors of tubulin polymerization and cell proliferation and also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.

TL;DR: The findings indicate A-289099 is a promising, orally active tubulin-binding compound with antitumor activity in vivo and closely associated with the regions of cell death.

TL;DR: Potent and orally bioavailable nonthiol-containing inhibitors of protein farnesyltransferase are described and p-Chlorophenylfuran ether 24 is 0.7 nM in vitro (FTase) and is 32% bioavailable in the mouse, 30% bio Available in rats, and 21% bio available in dogs.