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Andrew M. Petros
Researcher at AbbVie
Publications - 86
Citations - 10302
Andrew M. Petros is an academic researcher from AbbVie. The author has contributed to research in topics: FKBP & Nuclear magnetic resonance spectroscopy. The author has an hindex of 42, co-authored 83 publications receiving 9761 citations. Previous affiliations of Andrew M. Petros include Idun Pharmaceuticals & Abbott Laboratories.
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Journal ArticleDOI
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Tilman Oltersdorf,Steven W. Elmore,Alexander R. Shoemaker,Robert C. Armstrong,David J. Augeri,Barbara A. Belli,Milan Bruncko,Thomas L. Deckwerth,Jürgen Dinges,Philip J. Hajduk,Mary K. Joseph,Shinichi Kitada,Stanley J. Korsmeyer,Stanley J. Korsmeyer,Kunzer Aaron R,Anthony Letai,Chi Li,Michael J. Mitten,David G. Nettesheim,Shi Chung Ng,Paul Nimmer,Jacqueline M. O'Connor,Anatol Oleksijew,Andrew M. Petros,John C. Reed,Wang Shen,Stephen K. Tahir,Craig B. Thompson,Kevin J. Tomaselli,Baole Wang,Wendt Michael D,Haichao Zhang,Stephen W. Fesik,Saul H. Rosenberg +33 more
TL;DR: Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation.
Journal ArticleDOI
Structural biology of the Bcl-2 family of proteins.
TL;DR: The recently determined structure of the anti-apoptotic Bcl-w protein, the protein was also found to have a hydrophobic groove on its surface capable of binding BH3-containing proteins and peptides, which may explain why it is found predominately in the cytoplasm prior to activation.
Journal ArticleDOI
14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation
Sandeep Robert Datta,Alexander Y. Katsov,Linda Hu,Andrew M. Petros,Stephen W. Fesik,Michael B. Yaffe,Michael E. Greenberg +6 more
TL;DR: In this paper, survival factors trigger the phosphorylation of the pro-apoptotic Bcl-2 family member BAD at a site (Ser-155) within the BAD BH3 domain.
Journal ArticleDOI
Solution structure of the antiapoptotic protein bcl-2.
Andrew M. Petros,Ales Medek,David G. Nettesheim,Daniel H. Kim,Ho Sup Yoon,Kerry M. Swift,Edmund D. Matayoshi,Tilman Oltersdorf,Stephen W. Fesik +8 more
TL;DR: There are subtle differences in the hydrophobic binding groove in Bcl-2 that may translate into differences in antiapoptotic activity for the two isoforms, according to NMR spectroscopy.
Journal ArticleDOI
Rationale for Bcl-XL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies
Andrew M. Petros,David G. Nettesheim,Yi Wang,Edward T. Olejniczak,Robert P. Meadows,Jamey Mack,Kerry M. Swift,Edmund D. Matayoshi,Haichao Zhang,Craig B. Thompson,Stephen W. Fesik +10 more
TL;DR: A pair of 16‐residue peptides were designed and synthesized that were predicted to have a high helix propensity while maintaining the interactions important for complexation with Bcl‐XL and exhibited an enhanced affinity for B cl‐XL.