T
Thomas L. Deckwerth
Researcher at Idun Pharmaceuticals
Publications - 17
Citations - 4654
Thomas L. Deckwerth is an academic researcher from Idun Pharmaceuticals. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 11, co-authored 17 publications receiving 4435 citations. Previous affiliations of Thomas L. Deckwerth include Neurocrine Biosciences & Max Planck Society.
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Journal ArticleDOI
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Tilman Oltersdorf,Steven W. Elmore,Alexander R. Shoemaker,Robert C. Armstrong,David J. Augeri,Barbara A. Belli,Milan Bruncko,Thomas L. Deckwerth,Jürgen Dinges,Philip J. Hajduk,Mary K. Joseph,Shinichi Kitada,Stanley J. Korsmeyer,Stanley J. Korsmeyer,Kunzer Aaron R,Anthony Letai,Chi Li,Michael J. Mitten,David G. Nettesheim,Shi Chung Ng,Paul Nimmer,Jacqueline M. O'Connor,Anatol Oleksijew,Andrew M. Petros,John C. Reed,Wang Shen,Stephen K. Tahir,Craig B. Thompson,Kevin J. Tomaselli,Baole Wang,Wendt Michael D,Haichao Zhang,Stephen W. Fesik,Saul H. Rosenberg +33 more
TL;DR: Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation.
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Activation of Caspase-3 in Single Neurons and Autophagic Granules of Granulovacuolar Degeneration in Alzheimer’s Disease : Evidence for Apoptotic Cell Death
Christine Stadelmann,Thomas L. Deckwerth,Anu Srinivasan,Christian Bancher,Wolfgang Brück,Kurt A. Jellinger,Hans Lassmann +6 more
TL;DR: In this article, the activated form of caspase-3, the central effector enzyme of the apoptotic cascade, was detected in granules of granulovacuolar degeneration.
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Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
Thorsten Oost,Chaohong Sun,Robert C. Armstrong,Ali-Samer Al-Assaad,Stephen F. Betz,Thomas L. Deckwerth,Hong Ding,Steven W. Elmore,R. P. Meadows,Edward T. Olejniczak,Andrew Oleksijew,Tilman Oltersdorf,Saul H Rosenberg,Alexander R. Shoemaker,Kevin J. Tomaselli,Hua Zou,Stephen W. Fesik +16 more
TL;DR: The present study validates the BIR3 domain of XIAP as a target and supports the use of small molecule XIAP antagonists as a potential therapy for cancers that overexpress XIAP.
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Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussen's encephalitis.
Christian G. Bien,Jan Bauer,Thomas L. Deckwerth,Heinz Wiendl,Martina Deckert,Otmar D. Wiestler,Johannes Schramm,Christian E. Elger,Hans Lassmann +8 more
TL;DR: Findings indicate that a T‐cell–mediated cytotoxic reaction induces neuronal death in Rasmussen's encephalitis, and shows, for what is believed to be the first time, that a cytot toxic T‐ cell mechanism contributes to loss of neurons in human brain disease.
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Endoplasmic Reticulum Stress in PLP-Overexpressing Transgenic Rats: Gray Matter Oligodendrocytes Are More Vulnerable than White Matter Oligodendrocytes
Jan Bauer,Monika Bradl,Matthias Klein,Marianne Leisser,Thomas L. Deckwerth,Hartmut Wekerle,Hans Lassmann +6 more
TL;DR: In rats that overexpress PLP, impairment of PLP transport from the cell body to the processes interferes with the translocation of other membrane proteins such as myelin-associated glycop Protein (MAG) and myelin oligodendrocyte glycoprotein (MOG), but not with peripherally translated MBP.