Shi-Hao Tan

TL;DR: It is found that suppression of mammalian target of rapamycin activity by starvation or two mTOR catalytic inhibitors (PP242 and Torin1), but not by an allosteric inhibitor (rapamycin), leads to activation of lysosomal function.

TL;DR: It is found that PA, but not oleic acid, was able to cause an increase in autophagic flux, evidenced by LC3-II accumulation and formation of GFP-LC3 puncta, and inhibition of autophagy sensitized the cells to PA-induced apoptosis, suggesting the pro-survival function ofautophagy induced by PA.

TL;DR: The studies reveal a novel function of FOXO1 in HDACIs-mediated autophagy in human cancer cells and thus support the development of a novel therapeutic strategy by combining HDACs and autophagic inhibitors in cancer therapy.

TL;DR: This study demonstrates that ART treatment activates lysosomal function and then promotes ferritin degradation, subsequently leading to the increase of lysOSomal iron that is utilized by ART for its cytotoxic effect on cancer cells.

TL;DR: It is suggested that Andro could be a promising anti-cancer agent in combination therapy via its potent inhibitory effect on autophagy by disrupting autophagosome-lysosome fusion.